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. 2022 Aug:6:e2200138.
doi: 10.1200/PO.22.00138.

Constitutional Mosaicism: A Critical Issue in the Definition of BRCA-Inherited Cancer Risk

Elena Tenedini  1   2 , Simonetta Piana  3 , Angela Toss  1   4 , Marco Marino  2 , Elena Barbieri  4 , Lucia Artuso  2 , Marta Venturelli  4 , Elisa Gasparini  5 , Vincenzo Dario Mandato  6 , Isabella Marchi  4 , Sara Castellano  1 , Mario Luppi  1   4 , Tommaso Trenti  2 , Laura Cortesi  4 , Enrico Tagliafico  1   2   7
Affiliations

Constitutional Mosaicism: A Critical Issue in the Definition of BRCA-Inherited Cancer Risk

Elena Tenedini et al. JCO Precis Oncol. 2022 Aug.
No abstract available

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Conflict of interest statement

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/po/author-center.

Open Payments is a public database containing information reported by companies about payments made to US-licensed physicians (Open Payments).

Figures

FIG 1.
FIG 1.
Pedigree chart showing the tested patient and her family. In the diagram, the arrows indicate the patients who were tested in the different generations (roman numerals) and their age expressed in yo. *indicates same male subject. **indicates same pedigree diagram. mM/+, mosaic for mutation; M/+, heterozygous for mutation; +/+, no mutation; yo, years old.
FIG 2.
FIG 2.
Decisional algorithm to manage low VAF and interpret BRCA genetic test results in ovarian cancer. VAF, variant allele frequency.
See this image and copyright information in PMC

References

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