Strain differences in central nervous system neurotensin content between normotensive and spontaneously hypertensive rats

Abstract

Regional brain concentrations of neurotensin (NT) were measured in age-matched normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SH) rats. The relative distribution of NT was similar in the two strains with the hypothalamus having the highest concentration (55-75 pmol/g) and the cerebellum the lowest (3-6 pmol/g). In comparison to the WKY rats, the SH rats had significantly lower NT levels in the hypothalamus (-17%), medulla oblongata-pons (-18%), pituitary (-52%) and spinal cord (-44%). In view of the putative role of NT as a neurotransmitter and its cardiovascular effects following central and peripheral administration, the reduced levels of this peptide may be of importance in the higher blood pressure of the SH rat.