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. 2022 Sep 7;110(17):2709-2712.
doi: 10.1016/j.neuron.2022.08.004.

Why study mechanisms of brain stimulation therapies? To modulate the right neurons, in the right way, at the right time

Matthew J McGinley  1 , Steven T Lee  2
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Why study mechanisms of brain stimulation therapies? To modulate the right neurons, in the right way, at the right time

Matthew J McGinley et al. Neuron. .
Free article

Abstract

Clinical applications of vagus nerve stimulation (VNS) are burgeoning, but mechanistic work lags behind. In this issue of Neuron, Bowles and colleagues show that VNS timed with positive reinforcement improves motor learning and cortical function by a cholinergic mechanism.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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