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. 2022 Aug 23;23(17):9553.
doi: 10.3390/ijms23179553.

Investigation of the Associations of Novel Inflammatory Biomarkers-Systemic Inflammatory Index (SII) and Systemic Inflammatory Response Index (SIRI)-With the Severity of Coronary Artery Disease and Acute Coronary Syndrome Occurrence

Ewelina A Dziedzic  1   2 , Jakub S Gąsior  3 , Agnieszka Tuzimek  2 , Justyna Paleczny  4 , Adam Junka  4 , Marek Dąbrowski  5 , Piotr Jankowski  2   6
Affiliations

Investigation of the Associations of Novel Inflammatory Biomarkers-Systemic Inflammatory Index (SII) and Systemic Inflammatory Response Index (SIRI)-With the Severity of Coronary Artery Disease and Acute Coronary Syndrome Occurrence

Ewelina A Dziedzic et al. Int J Mol Sci. .

Abstract

Atherosclerosis, the underlying cause of coronary artery disease (CAD), has a significant inflammatory component. White blood cell count is an affordable and accessible way to assess the systemic immune response, as it comprises many subgroups with distinct and complex functions. Considering their multidirectional effect on atherosclerosis, new biomarkers integrating various leukocyte subgroups, the Systemic Inflammatory Index (SII) and the Systemic Inflammatory Response Index (SIRI), were recently devised to describe the balance between inflammation and immune reaction. This research aimed to evaluate the relationship of the intensity of inflammation measured by these biomarkers with the severity of CAD assessed with coronary angiography and with the diagnosis of acute coronary syndrome (ACS) or stable CAD in 699 patients. SIRI, but not SII, was associated with the diagnosis, having the highest values for patients with ACS (STEMI), significantly higher than in patients with stable CAD (p < 0.01). The highest SII and SIRI values were observed in patients with three-vessel CAD. SII and SIRI require further in-depth and well-designed research to evaluate their potential in a clinical setting.

Keywords: acute coronary syndrome; coronary angiography; coronary artery disease; systemic inflammatory index; systemic inflammatory response index.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Differences in SII (A) and SIRI (B) between patients with different CASSC.
Figure 2
Figure 2
Differences in SII (A) and SIRI (B) between patients with CASSC 0 and CASSC 1–3.
Figure 3
Figure 3
Differences in SII (A) and SIRI (B) between patients with stable CAD and ACS.
Figure 4
Figure 4
Differences in SII (A) and SIRI (B) between patients with STEMI, NSTEMI and UA.
Figure 5
Figure 5
Differences in SII (A) and SIRI (B) between patients with different diagnosis.
Figure 6
Figure 6
Correlation between SII (left panel) and SIRI (right panel) and age, BMI, and lipid profile.
Figure 7
Figure 7
Differences in SII (left panel) and SIRI (right panel) between patients with different diagnosis.
See this image and copyright information in PMC

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