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. 2022 Aug 29;23(17):9802.
doi: 10.3390/ijms23179802.

Molecular Biomarkers in Peri-Implant Health and Disease: A Cross-Sectional Pilot Study

Alejandra Chaparro  1 , Víctor Beltrán  2 , Daniel Betancur  3 , Ye-Han Sam  4 , Haniyeh Moaven  5 , Ali Tarjomani  4 , Nikolaos Donos  5 , Vanessa Sousa  4
Affiliations

Molecular Biomarkers in Peri-Implant Health and Disease: A Cross-Sectional Pilot Study

Alejandra Chaparro et al. Int J Mol Sci. .

Abstract

Background: The aim of this feasibility study was to investigate the concentration level of CCL-20/MIP-3α, BAFF/BLyS, IL-23, RANKL, and Osteoprotegerin in the Peri-Implant Crevicular Fluid (PICF), from patients diagnosed with peri-implant mucositis and peri-implantitis, and to compare them with PICF from patients with healthy implants.

Methods: Participants with at least one dental implant with healthy peri-implant tissues, peri-implant mucositis, or peri-implantitis were included. PICF was collected using paper strips from healthy and diseased peri-implant sites (n = 19). Biomarker levels were analyzed using a custom Multiplex ELISA Assay Kit.

Results: In comparison to peri-implant health, the peri-implant mucositis group showed an increased concentration of CCL-20 MIP-3α, BAFF/BLyS, IL-23, RANKL, and Osteoprotegerin. The peri-implantitis group had the lowest median concentration of Osteoprotegerin (1963 ng/mL); this group had a similar concentration of RANKL (640.84 ng/mL) when compared to the peri-implant health group. BAFF/BLyS (17.06 ng/mL) showed the highest concentration in the peri-implantitis group.

Conclusions: This feasibility study suggests that IL-23 and RANKL may help to elucidate the pathogenesis during the conversion from peri-implant health to peri-implantitis. Further research is required in BAFF/BLyS for the early diagnosis of peri-implantitis.

Keywords: BAFF/BlyS; CCL-20/MIP-3α; IL-23; Osteoprotegerin; RANKL; peri-implantitis.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Berglundh T., Armitage G., Araujo M.G., Avila-Ortiz G., Blanco J., Camargo P.M., Chen S., Cochran D., Derks J., Figuero E., et al. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J. Clin. Periodontol. 2018;45:S286–S291. doi: 10.1111/jcpe.12957. - DOI - PubMed
    1. Derks J., Tomasi C. Peri-implant health and disease. A systematic review of current epidemiology. J. Clin. Periodontol. 2015;42:S158–S171. doi: 10.1111/jcpe.12334. - DOI - PubMed
    1. Karoussis I.L., Kotsovilis S., Fourmousis I. A comprehensive and critical review of dental implant prognosis in periodontally compromised partially edentulous patients. Clin. Oral Implants Res. 2007;18:669–679. doi: 10.1111/j.1600-0501.2007.01406.x. - DOI - PubMed
    1. Kordbacheh K.C., Finkelstein J., Papapanou P.N. Peri-implantitis prevalence, incidence rate, and risk factors: A study of electronic health records at a U.S. dental school. Clin. Oral Implants Res. 2019;30:306–314. doi: 10.1111/clr.13416. - DOI - PubMed
    1. Pontoriero R., Tonelli M.P., Carnevale G., Mombelli A., Nyman S.R., Lang N.P. Experimentally induced peri-implant mucositis. A clinical study in humans. Clin. Oral Implants Res. 1994;5:254–259. doi: 10.1034/j.1600-0501.1994.050409.x. - DOI - PubMed

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