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Review
. 2022 Aug 31;23(17):9915.
doi: 10.3390/ijms23179915.

Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia

Ramona Gabriela Ursu  1 , Luminita Smaranda Iancu  1 , Elena Porumb-Andrese  2 , Costin Damian  1 , Roxana Gabriela Cobzaru  1 , Giorgio Nichitean  3 , Carmen Ripa  1 , Darius Sandu  3 , Ionut Luchian  4
Affiliations
Review

Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia

Ramona Gabriela Ursu et al. Int J Mol Sci. .

Abstract

Periodontal disease is a frequent pathology worldwide, with a constantly increasing prevalence. For the optimal management of periodontal disease, there is a need to take advantage of actual technology to understand the bacterial etiology correlated with the pathogenic mechanisms, risk factors and treatment protocols. We analyzed the scientific literature published in the last 5 years regarding the recent applications of mRNA analysis in periodontal disease for the main known bacterial species considered to be the etiological agents: Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia. We identified new pathogenic mechanisms, therapeutic target genes and possible pathways to prevent periodontal disease. The mRNA analysis, as well as the important technological progress in recent years, supports its implementation in the routine management of periodontal disease patients.

Keywords: animal model; biomarkers; cell lines; early detection; mRNA; periodontal disease; periodontitis; target therapy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Diagram of analyzed studies.
Figure 2
Figure 2
Periodontal and gingival health [14].
Figure 3
Figure 3
Classification of periodontitis [14].
See this image and copyright information in PMC

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