Comprehensive Treatment Algorithms of the Swiss Peritoneal Cancer Group for Peritoneal Cancer of Gastrointestinal Origin

Michel Adamina^{1

2}, Maxime Warlaumont^{3

4}, Martin D Berger⁵, Silvio Däster⁶, Raphaël Delaloye⁷, Antonia Digklia⁸, Beat Gloor⁹, Ralph Fritsch¹⁰, Dieter Koeberle^{11

12}, Thibaud Koessler¹³, Kuno Lehmann¹⁴, Phaedra Müller¹, Ralph Peterli⁶, Frédéric Ris¹⁵, Thomas Steffen¹⁶, Christian Stefan Weisshaupt¹⁷, Martin Hübner⁴

Affiliations

¹ Klinik für Viszeral- und Thoraxchirurgie, Kantonsspital Winterthur, 8401 Winterthur, Switzerland.
² Faculty of Medicine, University of Basel, 4056 Basel, Switzerland.
³ Chirurgie Digestive et Cancérologique, CHU de Lille, CH de Cambrai, 59000 Lille, France.
⁴ Department of Visceral Surgery, Lausanne University Hospital CHUV, University of Lausanne, 1011 Lausanne, Switzerland.
⁵ Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
⁶ Clarunis, Department of Visceral Surgery, University Centre for Gastrointestinal and Liver Diseases, St. Claraspital and University Hospital Basel, 4031 Basel, Switzerland.
⁷ Department of Medical Oncology, University Hospital Basel, 4031 Basel, Switzerland.
⁸ Department of Oncology, Lausanne University Hospital CHUV, University of Lausanne, 1011 Lausanne, Switzerland.
⁹ Department of Visceral Surgery and Medicine, Inselspital, University Bern, 3010 Bern, Switzerland.
¹⁰ Department of Medical Oncology and Hematology, University Hospital Zurich, 8091 Zurich, Switzerland.
¹¹ Department of Medical Oncology and Hematology, St. Claraspital, 4002 Basel, Switzerland.
¹² Faculty of Medicine, University of Bern, 3012 Bern, Switzerland.
¹³ Department of Oncology, Geneva University Hospital, 1205 Geneva, Switzerland.
¹⁴ Department of Surgery and Transplantation, University Hospital Zurich, 8091 Zurich, Switzerland.
¹⁵ Division of Digestive Surgery, University Hospitals of Geneva, 1205 Geneva, Switzerland.
¹⁶ Klinik für Allgemein-, Viszeral-, Endokrine und Transplantationschirurgie, Kantonsspital St. Gallen, 9000 St. Gallen, Switzerland.
¹⁷ Division of Medical Oncology and Hematology, Kantonsspital St. Gallen, 9000 St. Gallen, Switzerland.

PMID: 36077810
PMCID: PMC9454505
DOI: 10.3390/cancers14174275

Guideline

Comprehensive Treatment Algorithms of the Swiss Peritoneal Cancer Group for Peritoneal Cancer of Gastrointestinal Origin

Michel Adamina et al. Cancers (Basel). 2022.

. 2022 Sep 1;14(17):4275.

doi: 10.3390/cancers14174275.

Authors

Affiliations

¹ Klinik für Viszeral- und Thoraxchirurgie, Kantonsspital Winterthur, 8401 Winterthur, Switzerland.
² Faculty of Medicine, University of Basel, 4056 Basel, Switzerland.
³ Chirurgie Digestive et Cancérologique, CHU de Lille, CH de Cambrai, 59000 Lille, France.
⁴ Department of Visceral Surgery, Lausanne University Hospital CHUV, University of Lausanne, 1011 Lausanne, Switzerland.
⁵ Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
⁶ Clarunis, Department of Visceral Surgery, University Centre for Gastrointestinal and Liver Diseases, St. Claraspital and University Hospital Basel, 4031 Basel, Switzerland.
⁷ Department of Medical Oncology, University Hospital Basel, 4031 Basel, Switzerland.
⁸ Department of Oncology, Lausanne University Hospital CHUV, University of Lausanne, 1011 Lausanne, Switzerland.
⁹ Department of Visceral Surgery and Medicine, Inselspital, University Bern, 3010 Bern, Switzerland.
¹⁰ Department of Medical Oncology and Hematology, University Hospital Zurich, 8091 Zurich, Switzerland.
¹¹ Department of Medical Oncology and Hematology, St. Claraspital, 4002 Basel, Switzerland.
¹² Faculty of Medicine, University of Bern, 3012 Bern, Switzerland.
¹³ Department of Oncology, Geneva University Hospital, 1205 Geneva, Switzerland.
¹⁴ Department of Surgery and Transplantation, University Hospital Zurich, 8091 Zurich, Switzerland.
¹⁵ Division of Digestive Surgery, University Hospitals of Geneva, 1205 Geneva, Switzerland.
¹⁶ Klinik für Allgemein-, Viszeral-, Endokrine und Transplantationschirurgie, Kantonsspital St. Gallen, 9000 St. Gallen, Switzerland.
¹⁷ Division of Medical Oncology and Hematology, Kantonsspital St. Gallen, 9000 St. Gallen, Switzerland.

PMID: 36077810
PMCID: PMC9454505
DOI: 10.3390/cancers14174275

Abstract

Peritoneal cancer (PC) is a dire finding, yet in selected patients, long-term survival is possible. Complete cytoreductive surgery (CRS) together with combination immunochemotherapy is essential to achieve cure. Hyperthermic intraperitoneal chemotherapy (HIPEC) and pressurized intraperitoneal aerosol chemotherapy (PIPAC) are increasingly added to the multimodal treatment. The Swiss Peritoneal Cancer Group (SPCG) is an interdisciplinary group of expert clinicians. It has developed comprehensive treatment algorithms for patients with PC from pseudomyxoma peritonei, peritoneal mesothelioma, gastric, and colorectal origin. They include multimodal neoadjuvant treatment, surgical resection, and palliative care. The indication for and results of CRS HIPEC and PIPAC are discussed in light of the current literature. Institutional volume and clinical expertise required to achieve best outcomes are underlined, while inclusion of patients considered for CRS HIPEC and PIPAC in a clinical registry is strongly advised. The present recommendations are in line with current international guidelines and provide the first comprehensive treatment proposal for patients with PC including intraperitoneal chemotherapy. The SPCG comprehensive treatment algorithms provide evidence-based guidance for the multimodal care of patients with PC of gastrointestinal origin that were endorsed by all Swiss clinicians routinely involved in the multimodal care of these challenging patients.

Keywords: HIPEC; PIPAC; cytoreductive surgery; gastrointestinal cancer; hyperthermic intraperitoneal chemotherapy; peritoneal carcinomatosis; pressurized intraperitoneal chemotherapy.

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Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the content of this paper.

Figures

**Figure 1**
Treatment algorithm for pseudomyxoma peritonei.

**Figure 2**
Treatment algorithm for peritoneal mesothelioma.

**Figure 3**
Treatment algorithm for gastric cancer.

**Figure 4**
Treatment algorithm for colorectal cancer.

See this image and copyright information in PMC

References

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Comprehensive Treatment Algorithms of the Swiss Peritoneal Cancer Group for Peritoneal Cancer of Gastrointestinal Origin

Affiliations

Comprehensive Treatment Algorithms of the Swiss Peritoneal Cancer Group for Peritoneal Cancer of Gastrointestinal Origin

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

LinkOut - more resources

Full Text Sources