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Review
. 2022 Aug 26;12(17):2194.
doi: 10.3390/ani12172194.

The Future of Biomarkers in Veterinary Medicine: Emerging Approaches and Associated Challenges

Tharangani R W Perera  1 , David A Skerrett-Byrne  1 , Zamira Gibb  1 , Brett Nixon  1 , Aleona Swegen  1
Affiliations
Review

The Future of Biomarkers in Veterinary Medicine: Emerging Approaches and Associated Challenges

Tharangani R W Perera et al. Animals (Basel). .

Abstract

New biomarkers promise to transform veterinary practice through rapid diagnosis of diseases, effective monitoring of animal health and improved welfare and production efficiency. However, the road from biomarker discovery to translation is not always straightforward. This review focuses on molecular biomarkers under development in the veterinary field, introduces the emerging technological approaches transforming this space and the role of 'omics platforms in novel biomarker discovery. The vast majority of veterinary biomarkers are at preliminary stages of development and not yet ready to be deployed into clinical translation. Hence, we examine the major challenges encountered in the process of biomarker development from discovery, through validation and translation to clinical practice, including the hurdles specific to veterinary practice and to each of the 'omics platforms-transcriptomics, proteomics, lipidomics and metabolomics. Finally, recommendations are made for the planning and execution of biomarker studies with a view to assisting the success of novel biomarkers in reaching their full potential.

Keywords: biomarkers; genomics; lipidomics; metabolomics; proteomics; transcriptomics; veterinary.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Visual summary of proposed workflow for effective biomarker discovery and validation as discussed in this review [10,23,24,25,26,27,28,29,30,31,32,33].
See this image and copyright information in PMC

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