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. 2022 Aug 31;12(17):2247.
doi: 10.3390/ani12172247.

Relationship between FGF 23, SDMA, Urea, Creatinine and Phosphate in Relation to Feline Chronic Kidney Disease

Simona Grelová  1 , Martina Karasová  1 , Csilla Tóthová  2 , Terézia Kisková  3 , Darina Baranová  1 , Branislav Lukáč  1 , Mária Fialkovičová  1 , Alena Micháľová  1 , Lukáš Kunay  1 , Miroslav Svoboda  1
Affiliations

Relationship between FGF 23, SDMA, Urea, Creatinine and Phosphate in Relation to Feline Chronic Kidney Disease

Simona Grelová et al. Animals (Basel). .

Abstract

Chronic kidney disease (CKD) is a common diagnosis in older cats, and its prevalence increases with age. Conventional indirect biomarkers of glomerular filtration rate (GFR) have their limitations, and are not efficient in detecting early decreases in glomerular filtration rate. Recently, symmetric dimethylarginine (SDMA) concentrations have been proposed as a novel biomarker of GFR for the early detection of CKD. This study discusses the relationship between SDMA, FGF 23 and previously used indicators of kidney function, mainly creatinine, urea and phosphate. Ninety-nine cats were included in this study. Based on their SDMA values, 48 cats had CKD and the remaining 51 cats were used as a healthy control group. Serum of these cats was assayed for creatinine, urea and phosphate concentrations as well as FGF 23 values, and correlations between them were evaluated. Cats with CKD had higher FGF 23 concentrations than healthy cats, and no correlation was found between FGF 23 and SDMA, nor between FGF 23 and phosphate. On the other hand, phosphate strongly correlated with SDMA, urea and creatinine, making it a possible independent factor of CKD progression.

Keywords: cat; chronic kidney disease; fibroblast growth factor 23; symmetric dimethylarginine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Comparison of FGF 23 between healthy and CKD cats. Data are expressed as median ± SD. The data were analyzed using the Mann–Whitney U test. The box indicates the lower and upper quartile, and the central line is the median. The points at the ends of the whiskers are the 2.5 and 97.5% values. The box plot shows the serum level of FGF 23 in healthy and CKD cats. The FGF 23 level of CKD animals is significantly higher than in healthy controls. Significance vs. healthy animals is given as * p < 0.05.
Figure 2
Figure 2
Analysis of correlations (correlograms) among levels of selected parameters in healthy cats. CREA, creatinine; P, phosphate; Ca, calcium; SDMA, symmetric dimethylarginine; FGF 23, fibroblast growth factor 23. The coefficients of Pearson product-moment correlation are reported. Significance is given by *** p < 0.001.
Figure 3
Figure 3
Analysis of correlations (correlograms) among levels of selected parameters in the CKD group of cats. CREA, creatinine; P, phosphate; Ca, calcium; SDMA, symmetric dimethylarginine; FGF 23, fibroblast growth factor 23. The coefficients of Pearson product-moment correlation are reported. Significance is given by * p < 0.05 and *** p < 0.001.
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