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. 2022 Aug 30;11(17):5121.
doi: 10.3390/jcm11175121.

Intestinal Permeability and Depression in Patients with Inflammatory Bowel Disease

Miorita Melina Iordache  1   2 , Cristina Tocia  1   3 , Mariana Aschie  1   3   4   5 , Andrei Dumitru  1   3 , Mihaela Manea  4 , Georgeta Camelia Cozaru  3   4 , Lucian Petcu  6 , Sabina E Vlad  4 , Eugen Dumitru  1   3   4   5 , Anca Chisoi  3   4
Affiliations

Intestinal Permeability and Depression in Patients with Inflammatory Bowel Disease

Miorita Melina Iordache et al. J Clin Med. .

Abstract

Depression is a global health problem that requires an early and accurate diagnosis to ensure quick access to appropriate treatment. Among multiple psychopathological paths, recent attention has focused on analysing the brain-gut-microbiota axis. The intestinal barrier plays a key role, and dysfunctions occurring at this level have implications for mental health. The aim of the present study was to investigate the role of intestinal permeability biomarkers, i.e., calprotectin, zonulin, lipopolysaccharide-binding protein (LBP) and intestinal fatty acid-binding protein (I-FAB), in relation to depression in patients with inflammatory bowel disease (IBD). This is the first study of this kind taking place in Romania, Eastern Europe, with an emphasis on patients with Crohn's disease and ulcerative colitis. The correlations identified between depression and calprotectin and depression and LBP have the potential to shed light on the process of rapid diagnosis of depression with the help of biomarkers. Since depression is correlated with a decrease in the quality of life in patients with IBD, the need for access to appropriate treatments must be urgent.

Keywords: IFAB; LBP; biomarkers; calprotectin; leaky gut syndrome; psychiatric disorders; zonulin.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Spearman’s correlations between patients’ health score and biomarkers (a) calprotectin and (b) lipopolysaccharide-binding protein.
See this image and copyright information in PMC

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