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Review
. 2022 Sep 1;11(17):5167.
doi: 10.3390/jcm11175167.

Gender Differences in Diagnosis, Prevention, and Treatment of Cardiotoxicity in Cardio-Oncology

Shawn Simek  1   2 , Brian Lue  3 , Anjali Rao  1   2 , Goutham Ravipati  1 , Srilakshmi Vallabhaneni  1   2   4 , Kathleen Zhang  1   2   4 , Vlad G Zaha  1   2   4 , Alvin Chandra  1   2   4
Affiliations
Review

Gender Differences in Diagnosis, Prevention, and Treatment of Cardiotoxicity in Cardio-Oncology

Shawn Simek et al. J Clin Med. .

Abstract

Gender differences exist throughout the medical field and significant progress has been made in understanding the effects of gender in many aspects of healthcare. The field of cardio-oncology is diverse and dynamic with new oncologic and cardiovascular therapies approved each year; however, there is limited knowledge regarding the effects of gender within cardio-oncology, particularly the impact of gender on cardiotoxicities. The relationship between gender and cardio-oncology is unique in that gender likely affects not only the biological underpinnings of cancer susceptibility, but also the response to both oncologic and cardiovascular therapies. Furthermore, gender has significant socioeconomic and psychosocial implications which may impact cancer and cardiovascular risk factor profiles, cancer susceptibility, and the delivery of healthcare. In this review, we summarize the effects of gender on susceptibility of cancer, response to cardiovascular and cancer therapies, delivery of healthcare, and highlight the need for further gender specific studies regarding the cardiovascular effects of current and future oncological treatments.

Keywords: cancer; cardio-oncology; cardiotoxicity; cardiovascular disease; gender; sex.

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Conflict of interest statement

The authors declare no conflict of interest.

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