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. 2022 Aug 26;14(17):3519.
doi: 10.3390/nu14173519.

Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism-A Systematic Review

Alessio Danilo Inchingolo  1 , Angelo Michele Inchingolo  1 , Giuseppina Malcangi  1 , Pasquale Avantario  1 , Daniela Azzollini  1 , Silvio Buongiorno  1 , Fabio Viapiano  1 , Merigrazia Campanelli  1 , Anna Maria Ciocia  1 , Nicole De Leonardis  1 , Elisabetta de Ruvo  1 , Irene Ferrara  1 , Grazia Garofoli  1 , Valentina Montenegro  1 , Anna Netti  1 , Giulia Palmieri  1 , Antonio Mancini  1 , Assunta Patano  1 , Fabio Piras  1 , Grazia Marinelli  1 , Chiara Di Pede  1 , Claudia Laudadio  1 , Biagio Rapone  1 , Denisa Hazballa  1 , Alberto Corriero  2 , Maria Celeste Fatone  3 , Andrea Palermo  4 , Felice Lorusso  5 , Antonio Scarano  5 , Ioana Roxana Bordea  6 , Daniela Di Venere  1 , Francesco Inchingolo  1 , Gianna Dipalma  1
Affiliations

Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism-A Systematic Review

Alessio Danilo Inchingolo et al. Nutrients. .

Abstract

Phenolic compounds are natural phytochemicals that have recently reported numerous health benefits. Resveratrol, curcumin, and quercetin have recently received the most attention among these molecules due to their documented antioxidant effects. The review aims to investigate the effects of these molecules on bone metabolism and their role in several diseases such as osteopenia and osteoporosis, bone tumours, and periodontitis. The PubMed/Medline, Web of Science, Google Scholar, Scopus, Cochrane Library, and Embase electronic databases were searched for papers in line with the study topic. According to an English language restriction, the screening period was from January 2012 to 3 July 2022, with the following Boolean keywords: ("resveratrol" AND "bone"); ("curcumin" AND "bone"); ("quercetin" AND "bone"). A total of 36 papers were identified as relevant to the purpose of our investigation. The studies reported the positive effects of the investigated phenolic compounds on bone metabolism and their potential application as adjuvant treatments for osteoporosis, bone tumours, and periodontitis. Furthermore, their use on the titanium surfaces of orthopaedic prostheses could represent a possible application to improve the osteogenic processes and osseointegration. According to the study findings, resveratrol, curcumin, and quercetin are reported to have a wide variety of beneficial effects as supplement therapies. The investigated phenolic compounds seem to positively mediate bone metabolism and osteoclast-related pathologies.

Keywords: bone metabolism; bone tumours; diabetes; flavonoids; microbiota; oralbiotica; oralbiotics; osteoporosis; periodontitis; polyphenols.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic classification of phenolic compounds with chemical structures.
Figure 2
Figure 2
Representation of therapeutic properties of phenolic compounds on multiple human diseases.
Figure 3
Figure 3
Chemical formula of CIS-Resveratrol (A) E TRANS-Resveratrol (B).
Figure 4
Figure 4
Chemical formula of Quercetin.
Figure 5
Figure 5
Chemical formula of Curcumin.
Figure 6
Figure 6
Representation of the therapeutic properties of phenolic compounds on bone metabolism.
Figure 7
Figure 7
PRISMA flowchart diagram of the inclusion process.
Figure 8
Figure 8
Synthesis of the RB assessment of the in vitro studies.
Figure 9
Figure 9
Detail of the RB assessment of the in vitro studies included [76,89,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118].
Figure 10
Figure 10
Synthesis of the RB assessment of the in vivo studies.
Figure 11
Figure 11
Detail of the RB assessment of the in vivo studies included [57,104,119,120,121].
See this image and copyright information in PMC

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