Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Aug 26;27(17):5473.
doi: 10.3390/molecules27175473.

Dissipation, Processing Factors and Dietary Risk Assessment for Flupyradifurone Residues in Ginseng

Nan Fang  1   2 , Changpeng Zhang  2 , Zhongbin Lu  1 , Zhou Lu  3 , Zhongbei Zhang  4 , Bo Wang  1 , Zhiguang Hou  1 , Xueping Zhao  2
Affiliations

Dissipation, Processing Factors and Dietary Risk Assessment for Flupyradifurone Residues in Ginseng

Nan Fang et al. Molecules. .

Abstract

The massive use of pesticides has brought great risks to food and environmental safety. It is necessary to develop reliable analytical methods and evaluate risks through monitoring studies. Here, a method was used for the simultaneous determination of flupyradifurone (FPF) and its two metabolites in fresh ginseng, dried ginseng, ginseng plants, and soil. The method exhibited good accuracy (recoveries of 72.8-97.5%) and precision (relative standard deviations of 1.1-8.5%). The field experiments demonstrated that FPF had half-lives of 4.5-7.9 d and 10.0-16.9 d in ginseng plants and soil, respectively. The concentrations of total terminal residues in soil, ginseng plants, dried ginseng, and ginseng were less than 0.516, 2.623, 2.363, and 0.641 mg/kg, respectively. Based on these results, the soil environmental risk assessment shows that the environmental risk of FPF to soil organisms is acceptable. The processing factors for FPF residues in ginseng were 3.82-4.59, indicating that the concentration of residues increased in ginseng after drying. A dietary risk assessment showed that the risk of FPF residues from long-term and short-term dietary exposures to global consumers were 0.1-0.4% and 12.07-13.16%, respectively, indicating that the application of FPF to ginseng at the recommended dose does not pose a significant risk to consumers.

Keywords: analytical method; flupyradifurone; ginseng; mass spectrometry; pesticide residue analysis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Recovery of flupyradifurone, difluoroacetic acid, and 6-chloronicotinic acid in soil, fresh ginseng, and ginseng plants for the method using different proportions of water (0–50%) in the extraction solution.
Figure 2
Figure 2
Degradation kinetic curve of flupyradifurone in ginseng plants and soil: (a) ginseng plants; (b) soil.
Figure 3
Figure 3
Change of concentration of difluoroacetic acid and 6-chloronicotinic acid in ginseng plants: (a) difluoroacetic acid; (b) 6-chloronicotinic acid.
See this image and copyright information in PMC

References

    1. Yanan L., Dongyue Z., Min L., Chenyun H., Yong L., Wanlong D. Investigation of Pests and Diseases Occurrence and Pesticides Application in Main Producing Areas of Panax ginseng. Chin. Agric. Sci. Bull. 2014;30:294–298.
    1. Nauen R., Jeschke P., Velten R., Beck M.E., Ebbinghaus-Kintscher U., Thielert W., Wolfel K., Haas M., Kunz K., Raupach G. Flupyradifurone: A brief profile of a new butenolide insecticide. Pest Manag. Sci. 2015;71:850–862. doi: 10.1002/ps.3932. - DOI - PMC - PubMed
    1. Tan K., Wang C., Dong S., Li X., Nieh J.C. The pesticide flupyradifurone impairs olfactory learning in Asian honey bees (Apis cerana) exposed as larvae or as adults. Sci. Rep. 2017;7:17772. doi: 10.1038/s41598-017-18060-z. - DOI - PMC - PubMed
    1. Hesselbach H., Scheiner R.J.S.R. Effects of the novel pesticide flupyradifurone (Sivanto) on honeybee taste and cognition. Sci. Rep. 2018;8:4954. doi: 10.1038/s41598-018-23200-0. - DOI - PMC - PubMed
    1. Hesselbach H., Scheiner R. The novel pesticide flupyradifurone (Sivanto) affects honeybee motor abilities. Ecotoxicology. 2019;28:354–366. doi: 10.1007/s10646-019-02028-y. - DOI - PubMed

LinkOut - more resources