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Case Reports
. 2022 Aug 23:9:991558.
doi: 10.3389/fsurg.2022.991558. eCollection 2022.

Case report: Cardiac metastatic leiomyoma in an Asian female

Juan Li  1   2 , Hong Zhu  1   2 , Shuang-Ye Hu  3 , Shang-Qing Ren  2   4 , Xing-Lan Li  1   2
Affiliations
Case Reports

Case report: Cardiac metastatic leiomyoma in an Asian female

Juan Li et al. Front Surg. .

Abstract

Background: Uterine leiomyomas are the most common gynecological tumors in women of child-bearing age and premenopausal women, while benign metastasizing leiomyomas of the heart are rare.

Case presentation: We report a rare case of metastasizing leiomyoma in the heart of a 54-year-old woman 10 years after a uterine leiomyoma was discovered during hysterectomy. Echocardiography, cardiac plain scan and enhanced MRI at presentation showed a soft tissue signal mass in the right ventricle. A large cardiac mass attached to the chordae of the tricuspid valve and later shown to be histopathologically consistent with uterine leiomyoma was successfully resected through a right atriotomy.

Conclusions: Our case report highlights a rare type of tumor of the heart and suggests that metastasizing leiomyoma should be considered in the differential diagnosis of right-sided cardiac tumors. The complete surgical resection of the tumor was considered to be the best treatment.

Keywords: case report; heart; metastasizing leiomyoma; outcome; surgery.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Imaging of metastasizing leiomyoma. Enhanced MRI revealed soft tissue signal mass shadows in the outflow tract of the right ventricle.
Figure 2
Figure 2
Macropathology of metastasizing leiomyoma. The leiomyoma appeared as a solid, tough, grayish-white tubercle with no exact capsule.
Figure 3
Figure 3
Histological examination (HE) of metastasizing leiomyoma. (A,B) The spindle cell tumor showed clear boundaries, mild cell morphology, fascicular arrangement, and no mitotic figures (H&E staining, A: ×100, B: ×400).
Figure 4
Figure 4
Immunohistochemical (IHC) features of metastasizing leiomyoma. (Envision × 400) The spindle cells expressed desmin (A), caldesmon (B), PR (C), ER (D) and SMA (E). The calculated Ki67 labeling index was less than approximately 2% (F).
See this image and copyright information in PMC

References

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