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. 2021 Mar:11625:116250W.
Epub 2021 Mar 5.

ICG-based dynamic contrast-enhanced fluorescence imaging guided open orthopaedic surgery: pilot patient study

Shudong Jiang  1 , Jonathan T Elliott  2 , Jin Xing  1 , Xu Cao  1 , Xiaohan Yu  1 , Xinyue Han  1 , Rebecca E Dabrowski  2 , Melanie L Christian  2 , Eric R Henderson  2 , Brian W Pogue  1 , I Leah Gitajn  2
Affiliations

ICG-based dynamic contrast-enhanced fluorescence imaging guided open orthopaedic surgery: pilot patient study

Shudong Jiang et al. Proc SPIE Int Soc Opt Eng. 2021 Mar.

Abstract

Forty two patients with high energy open fractures were involved into the study to investigate whether an indocyanine green (ICG)-based dynamic contrast-enhanced fluorescence imaging (DCE-FI) can be used to objectively assess bone perfusion and guide surgical debridement. For each patient, fluorescence images were recorded after 0.1 mg/kg of ICG was administered intravenously. By utilizing a bone-specific kinetic model to the video sequences, the perfusion-related metrics were calculated. The results of this study shown that the quantitative ICG-based DEC-FI can accurately assess the human bone perfusion during the orthopedic surgery.

Keywords: bone vascular perfusion; debridement; dynamic contrast-enhanced fluorescence imaging; indocyanine green; orthopaedic surgery.

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Figures

Figure 1
Figure 1
Intraoperative imaging set-up.
Figure 2
Figure 2
Diagram of our imaging processing.
Figure 3
Figure 3
Images acquired intraoperatively during surgical treatment of a Gustilo Type 3C open tibia fracture with segmental bone loss. (a)White-light image, the circles #1-#4, were ROIs for imaging data analysis shown in (g); (b) and (c), fluorescence images were acquired at 75 sec. (b) and 215 sec. (c), after ICG injection; (d) and (e), LPF (d) and TBP(e) images; and (g), Temporal dynamic curves on ROIs shown in (a).
See this image and copyright information in PMC

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