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Review
. 2022 Aug 23:13:989816.
doi: 10.3389/fphys.2022.989816. eCollection 2022.

Metabolic acidosis post kidney transplantation

Hafsa Tariq  1 , Mirela Dobre  2
Affiliations
Review

Metabolic acidosis post kidney transplantation

Hafsa Tariq et al. Front Physiol. .

Abstract

Metabolic acidosis, a common complication in patients with chronic kidney disease (CKD), results in a multitude of deleterious effects. Though the restoration of kidney function following transplantation is generally accompanied by a correction of metabolic acidosis, a subset of transplant recipients remains afflicted by this ailment and its subsequent morbidities. The vulnerability of kidney allografts to metabolic acidosis can be attributed to reasons similar to pathogenesis of acidosis in non-transplant CKD, and to transplant specific causes, including donor related, recipient related, immune mediated factors, and immunosuppressive medications. Correction of metabolic acidosis in kidney transplantation either with alkali therapy or through dietary manipulations may have potential benefits and the results of such clinical trials are eagerly awaited. This review summarizes the published evidence on the pathogenesis and clinical consequences of chronic metabolic acidosis in kidney transplant recipients.

Keywords: graft failure; kidney transplant; metabolic acidosis; renal tubular acidosis; tubulointerstial injury.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Mechanisms of metabolic acidosis in kidney transplantation.
See this image and copyright information in PMC

References

    1. Alpern R. J., Sakhaee K. (1997). The clinical spectrum of chronic metabolic acidosis: homeostatic mechanisms produce significant morbidity. Am. J. Kidney Dis. 29 (2), 291–302. 10.1016/s0272-6386(97)90045-7 - DOI - PubMed
    1. Ambuhl P. M. (2007). Posttransplant metabolic acidosis: a neglected factor in renal transplantation? Curr. Opin. Nephrol. Hypertens. 16 (4), 379–387. 10.1097/MNH.0b013e3281bd8860 - DOI - PubMed
    1. Bailey J. L., Zheng B., Hu Z., Price S. R., Mitch W. E. (2006). Chronic kidney disease causes defects in signaling through the insulin receptor substrate/phosphatidylinositol 3-kinase/Akt pathway: implications for muscle atrophy. J. Am. Soc. Nephrol. 17 (5), 1388–1394. 10.1681/ASN.2004100842 - DOI - PubMed
    1. Batlle D. C., Mozes M. F., Manaligod J., Arruda J. A., Kurtzman N. A. (1981). The pathogenesis of hyperchloremic metabolic acidosis associated with kidney transplantation. Am. J. Med. 70 (4), 786–796. 10.1016/0002-9343(81)90534-9 - DOI - PubMed
    1. Bento L. M., Fagian M. M., Vercesi A. E., Gontijo J. A. (2007). Effects of NH4Cl-induced systemic metabolic acidosis on kidney mitochondrial coupling and calcium transport in rats. Nephrol. Dial. Transpl. 22 (10), 2817–2823. 10.1093/ndt/gfm306 - DOI - PubMed

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