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. 2022 Sep;7(3):212-220.
doi: 10.1177/23969873221099692. Epub 2022 May 12.

Cardiac CT for intra-cardiac thrombus detection in embolic stroke of undetermined source (ESUS)

Rani Barnea  1   2 , Inbar Nardi Agmon  2   3 , Gideon Shafir  2   4 , Shlomi Peretz  1   2 , Rom Mendel  1   2 , Jonathan Naftali  1   2 , Arthur Shiyovich  2   3 , Ran Kornowski  2   3 , Eitan Auriel  1   2 , Ashraf Hamdan  2   3 ; Cardiac CT for Undetermined Source of Embolic Stroke (CaCTUSES) Working Group
Affiliations

Cardiac CT for intra-cardiac thrombus detection in embolic stroke of undetermined source (ESUS)

Rani Barnea et al. Eur Stroke J. 2022 Sep.

Abstract

Introduction: Embolic stroke of undetermined source (ESUS) is a common medical challenge regarding secondary prevention strategy. Cardiac imaging is the cornerstone of embolic stroke workup, in an effort to diagnose high risk cardio-embolic sources. Cardiac computed tomography angiography (CCTA) is an emerging imaging modality with high diagnostic performance for intra-cardiac thrombus detection. The yield of CCTA implementation in addition to standard care in ESUS workup is unknown. Thus, the aim of this study was to assess the utility of CCTA in detecting intra-cardiac thrombi in the routine ESUS workup.

Patients and methods: This is a retrospective observational analysis of ESUS cases managed in vascular neurology unit between 2019 and 2021. Within this ESUS registry, consecutive patients undergoing CCTA were included and carefully analyzed.

Results: During the study period 1066 Ischemic stroke (IS) cases were treated and evaluated. 266/1066 (25%) met ESUS criteria and 129/266 (48%) underwent CCTA. Intra-cardiac thrombus was detected by CCTA in 22/129 (17%; 95% CI, 11.5%-23.5%) patients: left ventricular thrombus (LVT) in 13 (10.1%) patients, left atrial appendage (LAA) thrombus in 8 (6.2%) patients, and left atrial (LA) thrombus in 1 (0.8%) patient. Only 5/22 (23%) of these thrombi were suspected, but could not be confirmed, in trans-thoracic echocardiogram (TTE). Among CCTA-undergoing patients, 27/129 (21%; 95% CI, 14%-28%) were found to have an indication (including pulmonary embolism) for commencing anticoagulation (AC) treatment, rather than anti-platelets. In favor of CCTA implementation, 22/266 (8.2%; 95% CI, 4.9%-11.5%) patients within the entire ESUS cohort were diagnosed with intra-cardiac thrombus, otherwise missed.

Conclusion: CCTA improves the detection of intra-cardiac thrombi in addition to standard care in ESUS patients. The implementation of CCTA in routine ESUS workup can change secondary prevention strategy in a considerable proportion of patients.

Keywords: Embolic stroke of undetermined source (ESUS); cardiac-CT; intra-cardiac thrombus.

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Graphical abstract
Graphical abstract
Figure 1.
Figure 1.
Diagnostic flow-chart of all patients diagnosed with ischemic stroke during the study period. CT: computed tomography; ESUS: embolic stroke of undetermined source; LA: left atrium; LAA: left atrial appendage; LV: left ventricular; TEE: transesophageal echocardiography.
Figure 2.
Figure 2.
Selected images of intra-cardiac thrombi detected on cardiac CT scans. Representative left atrial appendage thrombus assessed on contrast enhanced CT images (a) and post-contrast CT scan (b). Representative left ventricular apical thrombus assessed on contrast enhanced CT images (c) and post-contrast CT scan (d).
See this image and copyright information in PMC

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