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Review
. 2022 Sep;77(9):510-515.

[Phage therapy, an additional strategy against multidrug-resistant bacteria]

[Article in French]
M Boniver  1 , P Wotquenne  2 , M Moutschen  3 , A F Rousseau  4
Affiliations
  • PMID: 36082597
Free article
Review

[Phage therapy, an additional strategy against multidrug-resistant bacteria]

[Article in French]
M Boniver et al. Rev Med Liege. 2022 Sep.
Free article

Abstract
in English, French

Phages are viruses that infect bacteria in a very specific way. They are naturally present throughout the biosphere and are also involved in various biological processes in humans. The beginning of the twentieth century saw the birth of phage therapy which consisted of using phages to fight against bacterial infections. Very quickly, however, the medical community turned away in favour of antibiotics. In recent years, bacteria that are multi-resistant to antibiotics have appeared and are giving rise to renewed interest in phages in the face of this therapeutic impasse. This review aims to rediscover phage therapy in the medical profession, by detailing its mechanisms of action, its clinical aspects and its practical modalities of use in Belgium. Future challenges are also outlined.

Les phages sont des virus qui infectent de façon très spécifique les bactéries. Ils sont naturellement présents dans toute la biosphère et sont également impliqués dans différents processus biologiques chez l’homme. Le début du vingtième siècle voit la naissance de la phagothérapie qui consiste à utiliser des phages pour lutter contre les infections bactériennes. Très vite pourtant, la communauté médicale s’en détourne au profit des antibiotiques.Ces dernières années, des bactéries multi-résistantes aux antibiotiques apparaissent et font naître un regain d’intérêt pour les phages face à cette impasse thérapeutique. Cette revue vise à faire redécouvrir la phagothérapie auprès du corps médical, en détaillant ses mécanismes d’action, ses aspects cliniques et ses modalités pratiques d’utilisation en Belgique. Les défis futurs sont également exposés.

Keywords: Antibiotic resistance; Infection; Phages; Phagotherapy.

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