New Mouse Model Suggests That Some Neuroendocrine Tumors May Originate From Neural Crest-Derived Cells

Affiliations

¹ Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, The Henry Wellcome Laboratory, Liverpool, United Kingdom. Electronic address: mark.pritchard@liverpool.ac.uk.

Editorial

D Mark Pritchard. Cell Mol Gastroenterol Hepatol. 2022.

. 2022;14(5):1170-1171.

doi: 10.1016/j.jcmgh.2022.08.005. Epub 2022 Sep 6.

¹ Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, The Henry Wellcome Laboratory, Liverpool, United Kingdom. Electronic address: mark.pritchard@liverpool.ac.uk.

No abstract available

Comment on

GFAP-directed Inactivation of Men1 Exploits Glial Cell Plasticity in Favor of Neuroendocrine Reprogramming.
Duan S, Sawyer TW, Sontz RA, Wieland BA, Diaz AF, Merchant JL. Duan S, et al. Cell Mol Gastroenterol Hepatol. 2022;14(5):1025-1051. doi: 10.1016/j.jcmgh.2022.06.009. Epub 2022 Jul 11. Cell Mol Gastroenterol Hepatol. 2022. PMID: 35835391 Free PMC article.

1. Dasari A., Shen C., Halperin D., Zhao B., Zhou S., Xu Y., Shih T., Yao J.C. Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States. JAMA Oncol. 2017;3:1335–1342. - PMC - PubMed
1. Cives M., Strosberg J.R. Gastroenteropancreatic neuroendocrine tumors. CA Cancer J Clin. 2018;68:471–487. - PubMed
1. Thakker R.V., Newey P.J., Walls G.V., Bilezikian J., Dralle H., Ebeling P.R., Melmed S., Sakurai A., Tonelli F., Brandi M.L., Endocrine S. Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1) J Clin Endocrinol Metab. 2012;97:2990–3011. - PubMed
1. Jiao Y., Shi C., Edil B.H., de Wilde R.F., Klimstra D.S., Maitra A., Schulick R.D., Tang L.H., Wolfgang C.L., Choti M.A., Velculescu V.E., Diaz L.A., Jr., Vogelstein B., Kinzler K.W., Hruban R.H., Papadopoulos N. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science. 2011;331:1199–1203. - PMC - PubMed
1. Crabtree J.S., Scacheri P.C., Ward J.M., Garrett-Beal L., Emmert-Buck M.R., Edgemon K.A., Lorang D., Libutti S.K., Chandrasekharappa S.C., Marx S.J., Spiegel A.M., Collins F.S. A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proc Natl Acad Sci U S A. 2001;98:1118–1123. - PMC - PubMed