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Comment
. 2022 Sep 9;7(1):314.
doi: 10.1038/s41392-022-01163-z.

For the sake of longevity: eating less and eating at the right time

Fei Sun  1   2 , Si Wang  3   4   5 , Guang-Hui Liu  6   7   8   9   10
Affiliations
Comment

For the sake of longevity: eating less and eating at the right time

Fei Sun et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Impacts of diet regimens on life expectancy. Five different CR feeding paradigms were designed to assess their beneficial effect on longevity. Male C57BL/6J mice were subjected to the AL diet for the first six weeks and then switched to a 30% CR purified diet for the rest of their life. Compared with ad libitum feeding, controlling daily calorie intake solely can improve the median lifespans by about 10%. Feeding CR diet to animals restrictedly in a 2-hour or 12-hour period during the day and minimally fasting animals for 12 h daily further extend median lifespans by another 10%. However, the most significant promotion of longevity was observed when combining CR with > 12-hour fasting interval and nocturnal feeding. Entraining circadian rhythm with the nocturnal feeding and diurnal fasting cycle can ultimately increase lifespans by about 35% in animals. AL Ad libitum, CR Caloric restriction
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