Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2023 Apr;68(4):1615-1631.
doi: 10.1007/s10620-022-07687-2. Epub 2022 Sep 9.

Effects of Hepatitis B Virus Infection on Patients with COVID-19: A Meta-Analysis

Yang Yu  1 , Xingzhao Li  2 , Taihu Wan  3
Affiliations
Meta-Analysis

Effects of Hepatitis B Virus Infection on Patients with COVID-19: A Meta-Analysis

Yang Yu et al. Dig Dis Sci. 2023 Apr.

Abstract

Background: The COVID-19 pandemic has brought new problems to patients infected with hepatitis B virus (HBV).

Aim: We aim to know the effects of HBV infection on patients with COVID-19.

Methods: We searched PubMed, Embase, and Web of Science for data and utilized Stata 14.0 software for this meta-analysis with a random-effects model. This paper was conducted in alignment with the preferred reporting items for systematic review and meta-analysis (PRISMA) guideline.

Results: In total, 37,696 patients were divided into two groups: 2591 COVID-19 patients infected with HBV in the experimental group and 35,105 COVID-19 patients not infected with HBV in the control group. Our study showed that the in-hospital mortality of the experimental group was significant higher than that of the control group (OR = 2.04, 95% CI 1.49-2.79). We also found that COVID-19 patients infected with HBV were more likely to develop severe disease (OR = 1.90, 95% CI 1.32-2.73) than COVID-19 patients not infected with HBV. Upon measuring alanine aminotransferase (SMD = 0.62, 95% CI 0.25-0.98), aspartate aminotransferase (SMD = 0.60, 95% CI 0.30-0.91), total bilirubin (SMD = 0.45, 95% CI 0.23-0.67), direct bilirubin (SMD = 0.36, 95% CI 0.24-0.47), lactate dehydrogenase (SMD = 0.32, 95% CI 0.18-0.47), we found that HBV infection led to significantly higher laboratory results in COVID-19 patients.

Conclusion: COVID-19 patients infected with HBV should receive more attention, and special attention should be given to various liver function indices during treatment.

Keywords: COVID-19; Hepatitis B virus; Liver function; Meta-analysis.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest.

Figures

Fig. 1
Fig. 1
Flow diagram of study selection
Fig. 2
Fig. 2
Forest plot of the effect of hepatitis B virus infection on in-hospital mortality among COVID-19 patients
Fig. 3
Fig. 3
Forest plot of the effect of hepatitis B virus infection on severity of COVID-19 patients
Fig. 4
Fig. 4
Forest plot of the effect of hepatitis B virus infection on alanine aminotransferase of COVID-19 patients
Fig. 5
Fig. 5
Forest plot of the effect of hepatitis B virus infection on aspartate aminotransferase of COVID-19 patients
Fig. 6
Fig. 6
Forest plot of the effect of hepatitis B virus infection on total bilirubin of COVID-19 patients
Fig. 7
Fig. 7
Forest plot of the effect of hepatitis B virus infection on direct bilirubin of COVID-19 patients
Fig. 8
Fig. 8
Forest plot of the effect of hepatitis B virus infection on lactate dehydrogenase of COVID-19 patients
Fig. 9
Fig. 9
Forest plot of the effect of hepatitis B virus infection on alkaline phosphatase of COVID-19 patients
Fig. 10
Fig. 10
Forest plot of the effect of hepatitis B virus infection on gamma-glutamyl transferase of COVID-19 patients
Fig. 11
Fig. 11
Forest plot of the effect of hepatitis B virus infection on albumin of COVID-19 patients
Fig. 12
Fig. 12
Forest plot of the effect of hepatitis B virus infection on globulin of COVID-19 patients
Fig. 13
Fig. 13
Forest plot of the effect of hepatitis B virus infection on creatine kinase of COVID-19 patients
Fig. 14
Fig. 14
Forest plot of the effect of hepatitis B virus infection on prothrombin time of COVID-19 patients
Fig. 15
Fig. 15
Forest plot of the effect of hepatitis B virus infection on activated partial thromboplastin time of COVID-19 patients
See this image and copyright information in PMC

Comment in

References

    1. Sim MR. The COVID-19 Pandemic: Major Risks to Healthcare and Other Workers on the Front Line. Occup Environ Med. 2020;77:281–282. doi: 10.1136/oemed-2020-106567. - DOI - PubMed
    1. COVID-19 Data in Motion: Tuesday, July 12, 2022. Available from: https://coronavirus.jhu.edu/map.html.
    1. Peeri NC, Shrestha N, Rahman MS, et al. The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? Int J Epidemiol. 2020;49:717–726. doi: 10.1093/ije/dyaa033. - DOI - PMC - PubMed
    1. Petrosillo N, Viceconte G, Ergonul O, et al. COVID-19, SARS and MERS: are they closely related? Clin Microbiol Infect. 2020;26:729–734. doi: 10.1016/j.cmi.2020.03.026. - DOI - PMC - PubMed
    1. Guo YR, Cao D, Hong ZS, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak-An update on the status. Mil Med Res. 2020;7:11. doi: 10.1186/s40779-020-00240-0. - DOI - PMC - PubMed

Publication types