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Clinical Trial
. 1978 Oct;136(4):494-500.
doi: 10.1016/0002-9610(78)90268-4.

A randomized trial of preoperative radiotherapy in cancer of the oropharynx and hypopharynx

M S Strong, C W Vaughan, H L Kayne, I M Aral, A Ucmakli, M Feldman, G B Healy
Clinical Trial

A randomized trial of preoperative radiotherapy in cancer of the oropharynx and hypopharynx

M S Strong et al. Am J Surg. 1978 Oct.

Abstract

One hundred patients with stage II and stage III cancer of the oropharynx and hypopharynx were treated under a protocol in which they were randomly selected for treatment by surgery alone or by combined preoperative radiotherapy and surgery. The schedule of preoperative radiation therapy chosen was 2,000 rads from a cobalt 60 machine delivered in five days. Eighty-six of the patients were evaluable at three years; there was no difference in the outcome of the treatment of the two groups. A similar study is urgently needed to determine the value of postoperative radiotherapy in the management of similar cancers.

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