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Meta-Analysis
. 2022 Sep 9;101(36):e30531.
doi: 10.1097/MD.0000000000030531.

High expression of ANRIL correlated with the poor prognosis in patients with cancer: A meta-analysis

Yun Liu  1   2 , Linqi Zhu  2 , Wenjun Zhao  2 , Yong Zhou  1 , Shihe Shao  2
Affiliations
Meta-Analysis

High expression of ANRIL correlated with the poor prognosis in patients with cancer: A meta-analysis

Yun Liu et al. Medicine (Baltimore). .

Abstract

Background: ANRIL, also called CDKN2B antisense RNA 1, is an important genetic susceptibility locus for cardiovascular diseases and associated with numerous pathologies, including several human cancers.

Objective: The relationship between ANRIL and the clinical outcome or prognosis of cancer patients was analyzed in this meta-analysis.

Methods: One thousand seven hundred eight cancer patients were selected in 23 studies from 3 databases (Pubmed, Cochrane Library, and EMBASE).

Results: A fixed-effects model indicated that the high expression of ANRIL is obviously linked to poor overall survival (OS) (Hazard ratio [HR] = 1.77, 95% confidence interval [CI] = 1.57-2.00, P < .00001); the random-effects model revealed poor disease-free survival (DFS) (HR = 1.86, 95% CI: 1.46-2.37, P < .00001). A high level of ANRIL expression was also associated with the tumor size (small vs large, odds ratio [OR] = 0.57, 95% CI: 0.39-0.83, P = .003), TNM stage (I + II vs III + IV; OR = 0.40, 95% CI: 0.24-0.69, P = .0008), and lymph node metastasis (LNM) (Yes vs No, OR = 3.66, 95% CI: 1.46-9.17, P = .006). ANRIL was not related significantly to histologic differentiation compared to poor with moderate + well; the OR value is 0.74, 95% CI: 0.26-2.12, P = .58. In addition, evidence suggested that a high level of ANRIL was positively associated with human cancer type, follow-up time, and sample size.

Conclusion: This meta-analysis demonstrated that ANRIL may be a valuable biomarker for predicting poor prognosis in cancer patients.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Forest plot for the relationship between the expression level of ANRIL with OS and DFS. (A) OS, (B) DFS. DFS = disease-free survival, OS = overall survival.
Figure 2.
Figure 2.
Forest plot of the expression of ANRIL and OR for clinicopathological parameters. The researched clinicopathological parameters are (A) tumor size, (B) TNM stage, (C) LNM, (D) histologic differentiation. OR = odds ratio, LNM = lymph node metastasis.
Figure 3.
Figure 3.
Evaluating the publication bias on OS (A) Funnel plot, (B) Begg funnel plot, (C) Egger publication bias plot. OS = overall survival.
Figure 4.
Figure 4.
The expression of ANRIL in different tumor tissues and the corresponding normal tissues.
Figure 5.
Figure 5.
The sensitivity analysis was used to analyze the effect of the individual studies on the pooled HRs for the relationship between ANRIL expression and OS. HR = hazard ration, OS = overall survival.
See this image and copyright information in PMC

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References

    1. Anna SC, Yumi K, Yusuke Y, et al. . Emerging roles of long non-coding RNA in cancer. Cancer Sci. 2018;109:2093–100. - PMC - PubMed
    1. Zhu B, Gong Y, Yan G, et al. . Down-regulation of lncRNA MEG3 promotes hypoxia-induced human pulmonary artery smooth muscle cell proliferation and migration via repressing PTEN by sponging miR-21. Biochem Biophys Res Commun. 2018;495:2125–32. - PubMed
    1. Huang YQ, Xiang B, Liu YH, et al. . LncRNA CDKN2B-AS1 promotes tumor growth and metastasis of human hepatocellular carcinoma by targeting let-7c-5p/NAP1L1 axis. Cancer Lett. 2018;437:56–66. - PubMed
    1. Hua L, Wang CY, Yao KH, et al. . High expression of long non-coding RNA ANRIL is associated with poor prognosis in hepatocellular carcinoma. Int J Clin Exp Pathol. 2015;8:3076–82. - PMC - PubMed
    1. Angenard G, Merdrignac A, Louis C, et al. . Expression of long non-coding RNA ANRIL predicts a poor prognosis in intrahepatic cholangiocarcinoma. Dig Liver Dis. 2019;51:1337–43. - PubMed

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