Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2022 Sep 9;101(36):e30302.
doi: 10.1097/MD.0000000000030302.

Does noninvasive cerebellar stimulation improve the balance and walking function of patients with stroke: A meta-analysis of randomized controlled trials

Zhi-Yuan Wu  1 , Yi-Qiao Wang  2 , Xiao-Peng Wen  1 , Mei-Ying Wang  1 , Li-Na Wang  1 , Li-Ming Lu  2 , Kun-Bin Li  1
Affiliations
Meta-Analysis

Does noninvasive cerebellar stimulation improve the balance and walking function of patients with stroke: A meta-analysis of randomized controlled trials

Zhi-Yuan Wu et al. Medicine (Baltimore). .

Abstract

Objectives: Investigating the efficacy and safety of noninvasive cerebellar stimulation in improving the balance and walking function of patients with stroke.

Methods: We searched 7 databases for randomized controlled trials (RCTs) related to noninvasive cerebellar stimulation in the treatment of stroke. The Berg Balance Scale (BBS), 6-minute walk test (6MWT), and Barthel Index (BI) were used as the outcome indexes to evaluate balance, walking and activities of daily living (ADL). The quality of the research was evaluated using the Cochrane Risk of Bias Tool. A meta-analysis was performed to evaluate the difference between the noninvasive cerebellar stimulation and control groups. Heterogeneity tests were performed to assess differences in treatment effects across noninvasive cerebellar stimulation modalities. A sensitivity analysis was performed to evaluate the robustness of the results.

Results: Seven studies were included, and 5 articles (71.43%) were rated as having a low risk of bias. Among the primary outcome indicators, 4 of the 7 articles were combined into the fixed effect model (I2 = 38%, P = .18). Compared with the control group, noninvasive cerebellar stimulation improved the BBS score, and the difference was statistically significant (mean difference [MD]: 3.00, 95% confidence interval [CI]: 1.10-5.40, P = .03); the sensitivity analysis showed that the statistical model was still stable after sequentially eliminating each article. Compared with the control group, noninvasive cerebellar stimulation improved the 6MWT results of patients with stroke (MD: 25.29, 95% CI: 4.86-45.73, P = .02). However, noninvasive cerebellar stimulation did not improve the BI (MD: 15.61, 95% CI: -7.91 to 39.13, P = .19). No safety problems or adverse reactions to noninvasive cerebellar stimulation were observed.

Conclusions: Noninvasive cerebellar stimulation improves balance and walking function of patients with stroke, but its effect on ADL is uncertain. Due to the methodological weaknesses in the included trials, more RCTs are needed to confirm our conclusions.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest for this study.

Figures

Figure 1.
Figure 1.
Screening process used in this study.
Figure 2.
Figure 2.
Effects of noninvasive cerebellar stimulation on the BBS. BBS = Berg Balance Scale.
Figure 3.
Figure 3.
Effects of noninvasive cerebellar stimulation on the 6MWT. 6MWT = 6-minute walk test.
Figure 4.
Figure 4.
Effects of noninvasive cerebellar stimulation on BI. BI = Barthel Index.
Figure 5.
Figure 5.
Risk of bias graph.
Figure 6.
Figure 6.
Sensitivity analysis of the primary indicator.
See this image and copyright information in PMC

References

    1. Horak FB, Diener HC. Cerebellar control of postural scaling and central set in stance. J Neurophysiol. 1994;72:479–93. - PubMed
    1. Ilg W, Synofzik M, Brötz D, et al. Intensive coordinative training improves motor performance in degenerative cerebellar disease. Neurology. 2009;73:1823–30. - PubMed
    1. Stoodley CJ. The cerebellum and neurodevelopmental disorders. Cerebellum. 2016;15:34–7. - PMC - PubMed
    1. Lefaucheur JP, Aleman A, Baeken C, et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): an update (2014-2018). Clin Neurophysiol. 2020;131:474–528. - PubMed
    1. Chung SW, Hill AT, Rogasch NC, et al. Use of theta-burst stimulation in changing excitability of motor cortex: a systematic review and meta-analysis. Neurosci Biobehav Rev. 2016;63:43–64. - PubMed

Publication types