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. 2023 Jan 1;118(1):168-173.
doi: 10.14309/ajg.0000000000001995. Epub 2022 Sep 6.

Correction and Prevention of Hyponatremia in Patients With Cirrhosis and Ascites: Post Hoc Analysis of the ANSWER Study Database

Giacomo Zaccherini  1 , Maurizio Baldassarre  1   2 , Manuel Tufoni  3 , Silvia Nardelli  4 , Salvatore Piano  5 , Carlo Alessandria  6 , Sergio Neri  7 , Francesco Giuseppe Foschi  8 , Fabio Levantesi  9 , Giorgio Bedogni  1   10 , Marco Domenicali  1   10 , Mauro Bernardi  1 , Paolo Caraceni  1   3 ; ANSWER Study Investigators
Affiliations

Correction and Prevention of Hyponatremia in Patients With Cirrhosis and Ascites: Post Hoc Analysis of the ANSWER Study Database

Giacomo Zaccherini et al. Am J Gastroenterol. .

Abstract

Introduction: We assessed the impact of long-term albumin administration to hyponatremic patients with ascites enrolled in the ANSWER trial.

Methods: The normalization rate of baseline hyponatremia and the 18-month incidence rate of at least moderate hyponatremia were evaluated.

Results: The hyponatremia normalization rate was higher with albumin than with standard medical treatment (45% vs 28%, P = 0.042 at 1 month). Long-term albumin ensured a lower incidence of at least moderate hyponatremia than standard medical treatment (incidence rate ratio: 0.245 [CI 0.167-0.359], P < 0.001).

Discussion: Long-term albumin administration improves hyponatremia and reduces episodes of at least moderate hyponatremia in outpatients with cirrhosis and ascites.

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References

    1. Angeli P, Wong F, Watson H, et al., CAPPS Investigators. Hyponatremia in cirrhosis: Results of a patient population survey. Hepatology 2006;44:1535–42.
    1. Llach J, Ginés P, Arroyo V, et al. Prognostic value of arterial pressure, endogenous vasoactive systems, and renal function in cirrhotic patients admitted to the hospital for the treatment of ascites. Gastroenterology 1988;94:482–7.
    1. Kim WR, Biggins SW, Kremers WK, et al. Hyponatremia and mortality among patients on the liver-transplant waiting list. N Engl J Med 2008;359:1018–26.
    1. Córdoba J, García-Martinez R, Simón-Talero M. Hyponatremic and hepatic encephalopathies: Similarities, differences and coexistence. Metab Brain Dis 2010;25:73–80.
    1. Londoño MC, Guevara M, Rimola A, et al. Hyponatremia impairs early post-transplantation outcome in patients with cirrhosis undergoing liver transplantation. Gastroenterology 2006;130:1135–43.

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