Detection of α-Synuclein-Specific T Cells in Parkinson's Disease

doi:10.1007/978-1-0716-2712-9_5

. 2022:2574:123-131.

doi: 10.1007/978-1-0716-2712-9_5.

Detection of α-Synuclein-Specific T Cells in Parkinson's Disease

Rekha Dhanwani^{1

2}, Alessandro Sette^{1

3}, Cecilia S Lindestam Arlehamn⁴

Affiliations

¹ Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA.
² Division of Extramural Activities, National Institute of Allergy and Infectious Diseases, National Institute of Health, Rockville, MD, USA.
³ Department of Medicine, University of California San Diego, La Jolla, CA, USA.
⁴ Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA. cecilia@lji.org.

PMID: 36087199
DOI: 10.1007/978-1-0716-2712-9_5

Detection of α-Synuclein-Specific T Cells in Parkinson's Disease

Rekha Dhanwani et al. Methods Mol Biol. 2022.

. 2022:2574:123-131.

doi: 10.1007/978-1-0716-2712-9_5.

Authors

Rekha Dhanwani^{1

2}, Alessandro Sette^{1

3}, Cecilia S Lindestam Arlehamn⁴

Affiliations

¹ Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA.
² Division of Extramural Activities, National Institute of Allergy and Infectious Diseases, National Institute of Health, Rockville, MD, USA.
³ Department of Medicine, University of California San Diego, La Jolla, CA, USA.
⁴ Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA. cecilia@lji.org.

PMID: 36087199
DOI: 10.1007/978-1-0716-2712-9_5

Abstract

Parkinson's disease (PD) is a widely prevalent chronic neurodegenerative disease. The disease is characterized by loss of dopaminergic neurons with abnormal aggregation of α-synuclein (α-syn). The misfolded deposition of α-syn is known to mount robust adaptive immune response by activating T cells. Here, we show that peripheral mononuclear cells when stimulated with a α-syn-derived peptide pool activate α-syn-specific T cells that produce cytokines.

Keywords: Adaptive immune response; Neurodegeneration; Parkinson’s disease; T cells; α-synuclein.

PubMed Disclaimer

Cited by

Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson's Disease.
Miller MR, Landis HE, Miller RE, Tizabi Y. Miller MR, et al. Cells. 2024 Sep 15;13(18):1554. doi: 10.3390/cells13181554. Cells. 2024. PMID: 39329738 Free PMC article. Review.

References

1. Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M (1997) Alpha-synuclein in Lewy bodies. Nature 388(6645):839–840. https://doi.org/10.1038/42166 - DOI - PubMed
1. Fahn S, Sulzer D (2004) Neurodegeneration and neuroprotection in Parkinson disease. NeuroRx 1(1):139–154. https://doi.org/10.1602/neurorx.1.1.139 - DOI - PubMed - PMC
1. Ueda K, Fukushima H, Masliah E, Xia Y, Iwai A, Yoshimoto M, Otero DA, Kondo J, Ihara Y, Saitoh T (1993) Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc Natl Acad Sci U S A 90(23):11282–11286. https://doi.org/10.1073/pnas.90.23.11282 - DOI - PubMed - PMC
1. Lashuel HA, Overk CR, Oueslati A, Masliah E (2013) The many faces of alpha-synuclein: from structure and toxicity to therapeutic target. Nat Rev Neurosci 14(1):38–48. https://doi.org/10.1038/nrn3406 - DOI - PubMed - PMC
1. Sulzer D, Alcalay RN, Garretti F, Cote L, Kanter E, Agin-Liebes J, Liong C, McMurtrey C, Hildebrand WH, Mao X, Dawson VL, Dawson TM, Oseroff C, Pham J, Sidney J, Dillon MB, Carpenter C, Weiskopf D, Phillips E, Mallal S, Peters B, Frazier A, Lindestam Arlehamn CS, Sette A (2017) T cells from patients with Parkinson’s disease recognize alpha-synuclein peptides. Nature 546(7660):656–661. https://doi.org/10.1038/nature22815 - DOI - PubMed - PMC

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- Springer
Medical
- MedlinePlus Health Information
Miscellaneous
- NCI CPTAC Assay Portal

[1] Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M (1997) Alpha-synuclein in Lewy bodies. Nature 388(6645):839–840. https://doi.org/10.1038/42166 - DOI - PubMed

[2] Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M (1997) Alpha-synuclein in Lewy bodies. Nature 388(6645):839–840. https://doi.org/10.1038/42166 - DOI - PubMed

[3] Fahn S, Sulzer D (2004) Neurodegeneration and neuroprotection in Parkinson disease. NeuroRx 1(1):139–154. https://doi.org/10.1602/neurorx.1.1.139 - DOI - PubMed - PMC

[4] Fahn S, Sulzer D (2004) Neurodegeneration and neuroprotection in Parkinson disease. NeuroRx 1(1):139–154. https://doi.org/10.1602/neurorx.1.1.139 - DOI - PubMed - PMC

[5] Ueda K, Fukushima H, Masliah E, Xia Y, Iwai A, Yoshimoto M, Otero DA, Kondo J, Ihara Y, Saitoh T (1993) Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc Natl Acad Sci U S A 90(23):11282–11286. https://doi.org/10.1073/pnas.90.23.11282 - DOI - PubMed - PMC

[6] Ueda K, Fukushima H, Masliah E, Xia Y, Iwai A, Yoshimoto M, Otero DA, Kondo J, Ihara Y, Saitoh T (1993) Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc Natl Acad Sci U S A 90(23):11282–11286. https://doi.org/10.1073/pnas.90.23.11282 - DOI - PubMed - PMC

[7] Lashuel HA, Overk CR, Oueslati A, Masliah E (2013) The many faces of alpha-synuclein: from structure and toxicity to therapeutic target. Nat Rev Neurosci 14(1):38–48. https://doi.org/10.1038/nrn3406 - DOI - PubMed - PMC

[8] Lashuel HA, Overk CR, Oueslati A, Masliah E (2013) The many faces of alpha-synuclein: from structure and toxicity to therapeutic target. Nat Rev Neurosci 14(1):38–48. https://doi.org/10.1038/nrn3406 - DOI - PubMed - PMC

[9] Sulzer D, Alcalay RN, Garretti F, Cote L, Kanter E, Agin-Liebes J, Liong C, McMurtrey C, Hildebrand WH, Mao X, Dawson VL, Dawson TM, Oseroff C, Pham J, Sidney J, Dillon MB, Carpenter C, Weiskopf D, Phillips E, Mallal S, Peters B, Frazier A, Lindestam Arlehamn CS, Sette A (2017) T cells from patients with Parkinson’s disease recognize alpha-synuclein peptides. Nature 546(7660):656–661. https://doi.org/10.1038/nature22815 - DOI - PubMed - PMC

[10] Sulzer D, Alcalay RN, Garretti F, Cote L, Kanter E, Agin-Liebes J, Liong C, McMurtrey C, Hildebrand WH, Mao X, Dawson VL, Dawson TM, Oseroff C, Pham J, Sidney J, Dillon MB, Carpenter C, Weiskopf D, Phillips E, Mallal S, Peters B, Frazier A, Lindestam Arlehamn CS, Sette A (2017) T cells from patients with Parkinson’s disease recognize alpha-synuclein peptides. Nature 546(7660):656–661. https://doi.org/10.1038/nature22815 - DOI - PubMed - PMC

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Detection of α-Synuclein-Specific T Cells in Parkinson's Disease

Affiliations

Detection of α-Synuclein-Specific T Cells in Parkinson's Disease

Authors

Affiliations

Abstract

Similar articles

Cited by

References

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous

Abstract

Similar articles

Cited by

References

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous