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. 2022:2574:123-131.
doi: 10.1007/978-1-0716-2712-9_5.

Detection of α-Synuclein-Specific T Cells in Parkinson's Disease

Rekha Dhanwani  1   2 , Alessandro Sette  1   3 , Cecilia S Lindestam Arlehamn  4
Affiliations

Detection of α-Synuclein-Specific T Cells in Parkinson's Disease

Rekha Dhanwani et al. Methods Mol Biol. 2022.

Abstract

Parkinson's disease (PD) is a widely prevalent chronic neurodegenerative disease. The disease is characterized by loss of dopaminergic neurons with abnormal aggregation of α-synuclein (α-syn). The misfolded deposition of α-syn is known to mount robust adaptive immune response by activating T cells. Here, we show that peripheral mononuclear cells when stimulated with a α-syn-derived peptide pool activate α-syn-specific T cells that produce cytokines.

Keywords: Adaptive immune response; Neurodegeneration; Parkinson’s disease; T cells; α-synuclein.

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