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. 2023 Jan;9(1):3-5.
doi: 10.1016/j.trecan.2022.08.003. Epub 2022 Sep 8.

Gut microbiota - a double-edged sword in cancer immunotherapy

Miles C Andrews  1 , Ajithkumar Vasanthakumar  2
Affiliations

Gut microbiota - a double-edged sword in cancer immunotherapy

Miles C Andrews et al. Trends Cancer. 2023 Jan.

Abstract

Immune checkpoint blockade (ICB) has revolutionized cancer treatment. However, many patients fail to respond to this therapy or experience side effects. Recently, gut microbiota have emerged as a key determinant of ICB efficacy and toxicity, making manipulation of the microbiome a novel therapeutic strategy with which to improve ICB outcomes.

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