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Comment
. 2022 Nov;8(11):881-883.
doi: 10.1016/j.trecan.2022.08.006. Epub 2022 Sep 8.

Battle of the γδ T cell subsets in the gut

Sofia Mensurado  1 , Bruno Silva-Santos  2
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Free article
Comment

Battle of the γδ T cell subsets in the gut

Sofia Mensurado et al. Trends Cancer. 2022 Nov.
Free article

Abstract

In a study in Science, Reis et al. describe a temporal segregation of γδ T cell activities in colorectal cancer (CRC). Initially tumor surveillance is orchestrated by interferon-γ (IFN-γ)-producing and cytotoxic γδ T cell subsets, but once the tumor thrives, it becomes infiltrated by interleukin (IL)-17+ γδ T cell subsets that promote its growth.

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Conflict of interest statement

Declaration of interests The authors declare no competing conflict of interest.

Comment on

  • TCR-Vγδ usage distinguishes protumor from antitumor intestinal γδ T cell subsets.
    Reis BS, Darcy PW, Khan IZ, Moon CS, Kornberg AE, Schneider VS, Alvarez Y, Eleso O, Zhu C, Schernthanner M, Lockhart A, Reed A, Bortolatto J, Castro TBR, Bilate AM, Grivennikov S, Han AS, Mucida D. Reis BS, et al. Science. 2022 Jul 15;377(6603):276-284. doi: 10.1126/science.abj8695. Epub 2022 Jul 14. Science. 2022. PMID: 35857588 Free PMC article.

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