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Comment
. 2022 Oct;43(10):780-781.
doi: 10.1016/j.it.2022.08.006. Epub 2022 Sep 8.

Hic et Runx: new insights into T cell tissue residency

Alexander D Clark  1 , Rémy Bosselut  2
Affiliations
Comment

Hic et Runx: new insights into T cell tissue residency

Alexander D Clark et al. Trends Immunol. 2022 Oct.

Abstract

Tissue-resident memory T cells (Trm), which typically do not enter the blood or lymphatic circulation at steady-state, are considered crucial for controlling pathogen entry at skin and mucosal barriers. Two recent studies (Fonseca et al. and Crowl et al.) shed light on the mechanisms of Trm cell differentiation.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

Figures

Figure 1.
Figure 1.. Transcriptional control of tissue residency.
CD4+ (red) or CD8+ (blue) Trm cells are found in various organs (left), in epithelia or underlying connective tissues (illustrated for the intestine, middle). Two recent studies [2,3] in mice document the transcriptomic patterns of CD4+ and CD8+ Trm cells, and highlight the role of transcription factors Hic1 and Runx3 in establishing tissue-residency by promoting the induction of TGFβ signaling-target genes.
See this image and copyright information in PMC

Comment on

References

    1. Rosato PC et al. (2020) Integrating resident memory into T cell differentiation models. Curr Opin Immunol 63, 35–42. 10.1016/j.coi.2020.01.001 - DOI - PMC - PubMed
    1. Fonseca R et al. (2022) Runx3 drives a CD8(+) T cell tissue residency program that is absent in CD4(+) T cells. Nat Immunol 23, 1236–1245. 10.1038/s41590-022-01273-4 - DOI - PubMed
    1. Crowl JT et al. (2022) Tissue-resident memory CD8(+) T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments. Nat Immunol 23, 1121–1131. 10.1038/s41590-022-01229-8 - DOI - PMC - PubMed
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    1. Borges da Silva H et al. (2020) Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8(+) Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β. Immunity 53, 158–171.e156. 10.1016/j.immuni.2020.06.010 - DOI - PMC - PubMed

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