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Review
. 2022 Aug;39(4):645-650.
doi: 10.5114/ada.2022.118919. Epub 2022 Sep 1.

The role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the pathophysiology of psoriasis and systemic lupus erythematosus

Aleksandra Frątczak  1 , Karina Polak  1 , Michał Szczepanek  1 , Anna Lis-Święty  1
Affiliations
Review

The role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the pathophysiology of psoriasis and systemic lupus erythematosus

Aleksandra Frątczak et al. Postepy Dermatol Alergol. 2022 Aug.

Abstract

Inflammation and atherogenic dyslipidaemia are often observed in skin diseases and represent an increased risk of cardiovascular disorders. Proprotein convertase subtilisin/kexin type 9 plays an important role in the regulation of serum low-density lipoprotein cholesterol levels. Its biological role, however, seems to go much beyond the regulation of cholesterol metabolism. The article presents potential pathophysiological links between inflammatory process and lipid disorders based on the example of psoriasis and systemic lupus erythematosus.

Keywords: PCSK9; alirocumab; evolocumab; psoriasis; systemic lupus erythematosus.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in lipid metabolism. PCSK9 (brown) binds to the low-density lipoprotein receptor (LDL-R) (green), promoting its lysosomal degradation
Figure 2
Figure 2
Mechanism of action for proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies. Monoclonal antibodies against PCSK9 (red) block binding of PCSK9 (brown) to the low-density lipoprotein receptor (LDL-R) (green) and prevent LDL-R degradation, which results in a higher LDL receptor recycling and reduced serum LDL level
See this image and copyright information in PMC

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