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Case Reports
. 2022 May 31;5(5):358-361.
doi: 10.1002/iju5.12488. eCollection 2022 Sep.

Paraurachal paraganglioma

Masafumi Tsuruta  1 , Takayuki Goto  1 , Jin Kono  1 , Yuki Kita  1 , Kimihiko Masui  1 , Takeshi Sano  1 , Masakazu Fujimoto  2 , Atsuro Sawada  1 , Shusuke Akamatsu  1 , Takashi Kobayashi  1
Affiliations
Case Reports

Paraurachal paraganglioma

Masafumi Tsuruta et al. IJU Case Rep. .

Abstract

Introduction: Paragangliomas (PGLs) are frequently reported around the abdominal aorta; however, are extremely rare near the urachus.

Case presentation: A 78-year-old woman was referred to the urology department of our hospital for further examination and treatment of a 1.2-cm tumor in the lower abdominal wall, a tumor excision was then performed. On immunohistochemical staining, the tumor and supporting cells were positive for chromogranin A and the S 100 protein, respectively, and were diagnosed as PGL. The PGL was thought to be derived from chromaffin cells that migrated to the wall of the urachus during embryonic life and remained even after the wall regressed.

Conclusion: We report a case of PGL near the urachus that can be explained by the distribution of the sympathetic network around the midline of the lower abdominal wall during embryonic development. Therefore, PGL should be considered in the differential diagnosis of periurachal tumors.

Keywords: chromaffin cells; paraganglioma; urachus.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Images of the lower abdominal tumor (arrowhead). (a) A 1.2‐cm tumor was found in the midline of the lower abdominal wall on an axial view of the computed tomography (CT). (b), (c) Axial and sagittal view of fluorodeoxyglucose positron emission tomography‐computed tomography (FDG‐PET/CT) showed intense FDG uptake (maximum standardized uptake value, SUVmax, 4.51).
Fig. 2
Fig. 2
On histopathological examination, the tumor had basophilic granular cytoplasm, surrounded by fibrovascular stroma (hematoxylin–eosin, 400×) (a). On immunohistochemical staining, the tumor cells are positive for chromogranin A (400×) (b), and supporting cells are positive for S 100 protein (400×) (c).
See this image and copyright information in PMC

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