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. 2022 Aug 25:13:976247.
doi: 10.3389/fphar.2022.976247. eCollection 2022.

Effects of Piper sarmentosum Roxb. on hypertension and diabetes mellitus: A systematic review and meta-analysis

Nur Syakirah Othman  1 , Nur Aishah Che Roos  2 , Amilia Aminuddin  1 , Jaya Kumar Murthy  1 , Adila A Hamid  1 , Azizah Ugusman  1
Affiliations

Effects of Piper sarmentosum Roxb. on hypertension and diabetes mellitus: A systematic review and meta-analysis

Nur Syakirah Othman et al. Front Pharmacol. .

Abstract

Hypertension and diabetes mellitus are among the most prevalent diseases affecting people from all walks of life. Medicinal herbs have garnered interest as potential agents for the prevention and treatment of diabetes mellitus and hypertension due to their multiple beneficial effects. Piper sarmentosum Roxb. (PS) is an edible medicinal plant that has been traditionally used in Asia for treating hypertension and diabetes mellitus. This review is aimed to provide comprehensive information from the literature on the effects of PS on hypertension and diabetes mellitus. A computerized database search was performed on Scopus, PubMed and Web of Science databases with the following set of keywords: Piper sarmentosum AND diabetes mellitus OR diabetic OR diabetes OR hyperglyc*emia OR blood glucose OR HbA1c OR glycated h*emoglobin OR h*emoglobin A1c OR hyperten* OR blood pressure. A total of 47 articles were screened and 14 articles published between the years 1998 until 2021 were included for data extraction, comprising of six articles on antihypertensive and eight articles on antidiabetic effects of PS. These studies consist of two in vitro studies and eleven in vivo animal studies. Meta-analysis of three studies on hypertension showed that PS versus no treatment significantly lowered the systolic blood pressure with mean difference (MD) -39.84 mmHg (95% confidence interval (CI) -45.05, -34.62; p < 0.01), diastolic blood pressure with MD -26.68 mmHg (95% CI -31.48, -21.88; p < 0.01), and mean arterial pressure with MD -30.56 mmHg (95% CI -34.49, -26.63; p < 0.01). Most of the studies revealed positive effects of PS against hypertension and diabetes mellitus, suggesting the potential of PS as a natural source of antidiabetic and antihypertensive agents.

Keywords: Piper sarmentosum; antidiabetic; antihypertensive; diabetes mellitus; hypertension.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Piper sarmentosum Roxb. Leaves (A) and fruit (B).
FIGURE 2
FIGURE 2
The selection process of the articles according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline.
FIGURE 3
FIGURE 3
Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) risk of bias summary: review authors’ judgements about each risk of bias item for each included study.
FIGURE 4
FIGURE 4
The Joanna Briggs Institute (JBI) critical appraisal checklist summary for reporting in vitro studies.
FIGURE 5
FIGURE 5
Meta-analysis of the effects of Piper sarmentosum Roxb. versus control on blood pressure: (A) SBP, Systolic blood pressure; (B) DBP, diastolic blood pressure, (C) MAP, mean arterial pressure.
FIGURE 6
FIGURE 6
Meta-analysis of the effects of Piper sarmentosum Roxb. versus positive control on blood pressure: (A) SBP, Systolic blood pressure; (B) DBP, diastolic blood pressure, (C) MAP, mean arterial pressure.
FIGURE 7
FIGURE 7
Sensitivity analysis of the effects of 500 mg/kg Piper sarmentosum Roxb. versus control on blood pressure: (A) SBP, Systolic blood pressure; (B) DBP, diastolic blood pressure, (C) MAP, mean arterial pressure.
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