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Review
. 2022 Aug 25:13:927083.
doi: 10.3389/fphar.2022.927083. eCollection 2022.

U0126: Not only a MAPK kinase inhibitor

Yijie You  1 , Yunlian Niu  2 , Jian Zhang  1 , Sheng Huang  1 , Peiyuan Ding  1 , Fengbing Sun  1 , Xuhui Wang  1   3
Affiliations
Review

U0126: Not only a MAPK kinase inhibitor

Yijie You et al. Front Pharmacol. .

Abstract

U0126, as an inhibitor of the MAPK signaling pathway, is closely related to various biological processes, such as differentiation, cell growth, autophagy, apoptosis, and stress responses. It makes U0126 play an essential role in balancing cellular homeostasis. Although U0126 has been suggested to inhibit various cancers, its complete mechanisms have not been clarified in cancers. This review summarized the most recent and relevant research on the many applications of U0126 and described its role and mechanisms in different cancer cell types. Moreover, some acknowledged functions of U0126 researched in the laboratory were listed in our review. We discussed the probability of using U0126 to restain cancers or suppress the MAPK pathway as a novel way of cancer treatment.

Keywords: MAPK inhibitors; MAPK signal pathway; U0126; cancer; cancer therapy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The known MAPK signaling pathways downstream target cell receptor signaling, working cooperatively to regulate cell physiology.
FIGURE 2
FIGURE 2
The structure and chemical characteristics of three isomers of U0126. (A) U0126, Z,Z-isomer; (B) U0126, Z,E-isomer; (C) U0126, E,E-isomer.
See this image and copyright information in PMC

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References

    1. Adhikary S., Eilers M. (2005). Transcriptional regulation and transformation by Myc proteins. Nat. Rev. Mol. Cell Biol. 6, 635–645. 10.1038/nrm1703 - DOI - PubMed
    1. Aguirre Ghiso J. A., Alonso D. F., Farías E. F., Gomez D. E., de Kier Joffè E. B. (1999). Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype. Eur. J. Biochem. 263, 295–304. 10.1046/j.1432-1327.1999.00507.x - DOI - PubMed
    1. Ajiki T., Fujimori T., Onoyama H., Yamamoto M., Kitazawa S., Maeda S., et al. (1996). K-ras gene mutation in gall bladder carcinomas and dysplasia. Gut 38, 426–429. 10.1136/gut.38.3.426 - DOI - PMC - PubMed
    1. Bachireddy P., Bendapudi P. K., Felsher D. W. (2005). Getting at MYC through RAS. Clin. cancer Res. official J. Am. Assoc. Cancer Res. 11, 4278–4281. 10.1158/1078-0432.ccr-05-0534 - DOI - PubMed
    1. Baines P., Fisher J Fau - Truran L., TruranFau - Davies L. E., Davies E Fau - Hallett M., Hallett M Fau - Hoy T., Hoy T Fau - Burnett A. K., et al. (2002). The MEK inhibitor, PD98059, reduces survival but does not block acute myeloid leukemia blast maturation in vitro . Eur. J. Haematol. 64, 211–218. 10.1034/j.1600-0609.2000.90139.x - DOI - PubMed

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