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Review
. 2022 Aug 25:28:1610588.
doi: 10.3389/pore.2022.1610588. eCollection 2022.

Clinicopathologic Features and Treatment of CD10-Positive Mantle Cell Lymphoma: A Case Report and Review of Literature

Christopher Hino  1 , Bryan Pham  1 , Austin L Gray  2 , Jun Wang  2 , Dan Ran Castillo  3 , Mojtaba Akhtari  3 , Yan Liu  2
Affiliations
Review

Clinicopathologic Features and Treatment of CD10-Positive Mantle Cell Lymphoma: A Case Report and Review of Literature

Christopher Hino et al. Pathol Oncol Res. .

Abstract

Mantle cell lymphoma (MCL) is a rare and aggressive non-Hodgkin's B cell lymphoma characterized by the translocation t(11;14) (q13;32) and overexpression of CCND1. MCL is immunophenotypically identified as CD20+, CD5+, CyclinD1+, CD43+, CD10-, BCL6-, and CD23-. It is often distinguished from B cell lymphomas of germinal center cell origin by the absence of CD10 expression. Here we report the unique clinicopathologic features of a patient with CD10+ MCL with gastrointestinal involvement and review current literature identifying this unique immunophenotype.

Keywords: B-cell chronic lymphoproliferative disorders; CCND1; CD10; case report; immunophenotyping; mantle cell lymphoma.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Immunohistochemistry of CD10+ mantle cell lymphoma. Representative lymph node biopsy demonstrates (A) morphologic features of the mantle cell lymphoma (H&E, x1,000) with immunostaining (B) positive for CD5, (C) positive for cyclin D1, (D) Variabily positive for CD10, (E) negative for CD23, (F) Elevated Ki-67 proliferation index (Overall 40%–70%).
FIGURE 2
FIGURE 2
Flow cytometric analysis of bone marrow aspirate revealed a monotypic lambda restricted CD5+/CD10+ B cell population.
FIGURE 3
FIGURE 3
PET-CT demonstrating hypermetabolic , diffuse wall thickening of the stomach and throughout the small bowel.
See this image and copyright information in PMC

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References

    1. Jain P, Wang M. Mantle Cell Lymphoma: 2019 Update on the Diagnosis, Pathogenesis, Prognostication, and Management. Am J Hematol (2019) 94(6):710–25. 10.1002/ajh.25487 PubMed Abstract | 10.1002/ajh.25487 | Google Scholar - DOI - DOI - PubMed
    1. Teras LR, DeSantis CE, Cerhan JR, Morton LM, Jemal A, Flowers CR. US Lymphoid Malignancy Statistics by World Health Organization Subtypes: 2016 US Lymphoid Malignancy Statistics by World Health Organization Subtypes. CA Cancer J Clin (20162016) 66(6):443–59. 10.3322/caac.21357 10.3322/caac.21357 | Google Scholar - DOI - DOI - PubMed
    1. Bosch F, L, pez-Guillermo A, Campo E, Ribera JM, Conde E, et al. Mantle Cell Lymphoma: Presenting Features, Response to Therapy, and Prognostic Factors. Cancer (1998) 82(3):567–75. 10.1002/(sici)1097-0142(19980201)82:3<567::aid-cncr20>3.0.co;2-z PubMed Abstract | 10.1002/(sici)1097-0142(19980201)82:3<567::aid-cncr20>3.0.co;2-z | Google Scholar - DOI - DOI - PubMed
    1. Campo E, Raffeld M, Jaffe ES. Mantle-cell Lymphoma. Semin Hematol (1999) 36(2):115–27. PubMed Abstract | Google Scholar - PubMed
    1. Jares P, Colomer D, Campo E. Genetic and Molecular Pathogenesis of Mantle Cell Lymphoma: Perspectives for New Targeted Therapeutics. Nat Rev Cancer (2007) 7(10):750–62. 10.1038/nrc2230 PubMed Abstract | 10.1038/nrc2230 | Google Scholar - DOI - DOI - PubMed