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Case Reports
. 2022 May 3;2(3):e121.
doi: 10.1002/ski2.121. eCollection 2022 Sep.

An unusual growth in the nail matrix: A case of superficial acral fibromyxoma

Genevieve Ho  1   2 , Caroline Kurek  3 , David Stewart  1   4 , Linda K Martin  1   2   5
Affiliations
Case Reports

An unusual growth in the nail matrix: A case of superficial acral fibromyxoma

Genevieve Ho et al. Skin Health Dis. .

Abstract

We describe a case of superficial acral fibromyxoma arising within the germinal matrix of the index finger. This is an uncommon localisation of this relatively newly described benign soft tissue tumour. Herein, we discuss the varied clinical presentation, distinguishing histopathological features and important differential diagnoses for this condition.

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Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

FIGURE 1
FIGURE 1
Dermoscopy image of patient's right index fingernail showing focal longitudinal trachyonychia, onychorrhexis and subungual haemorrhage
FIGURE 2
FIGURE 2
(a) Bland spindle and stellate cells with a myxoid stroma within the superficial dermis in a loosely fascicular pattern (H&E, 100x magnification); (b) Tumour cells are strong and diffusely positive for CD34 (200x magnification); (c) Loss of RB‐1 expression in the lesional stroma, with only uptake highlighting blood vessels, mast cells and lymphocytes (200x magnification); (d) Low power magnification showing intracorneal haemorrhage (H&E stain, 40x magnification)
See this image and copyright information in PMC

References

    1. Fetsch JF, Laskin WB, Miettinen M. Superficial acral fibromyxoma: a clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes. Hum Pathol. 2001;32(7):704–14. 10.1053/hupa.2001.25903 - DOI - PubMed
    1. Crepaldi BE, Soares RD, Silveira FD, Taira RI, Hirakawa CK, Matsumoto MH. Fibromixoma superficial acral: revisão da literatura. Revista Brasileira de Ortopedia; 2018. - PMC - PubMed
    1. Hollmann TJ, Bovée JVMG, Fletcher CDM. Digital fibromyxoma (superficial acral fibromyxoma): a detailed characterization of 124 cases. Am J Surg Pathol. 2012;36(6):789–98. 10.1097/pas.0b013e31824a0b83 - DOI - PubMed
    1. Sawaya JL, Khachemoune A. Superficial acral fibromyxoma. Int J Dermatol. 2015;54(5):499–508. 10.1111/ijd.12750 - DOI - PubMed
    1. Chabbab F, Metz T, Theunis A, Richert B. Superficial acral fibromyxoma in a sub‐matricial location: an unusual variant. In: Annales de Dermatologie et de Venereologie; 2014. p. 94–105. - PubMed

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