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. 2022 Sep 5;12(3):148-153.
doi: 10.1055/s-0042-1755389. eCollection 2022 Jul.

Serum SCUBE-1 Levels and Return of Spontaneous Circulation Following Cardiopulmonary Resuscitation in Adult Patients

Cahit Yılmaz  1 , Bedia Gülen  2 , Ertan Sönmez  3 , Dursun Akbay  4 , Özgür Söğüt  5 , Serdar Özdemir  1 , Ömer Faruk Özer  6
Affiliations

Serum SCUBE-1 Levels and Return of Spontaneous Circulation Following Cardiopulmonary Resuscitation in Adult Patients

Cahit Yılmaz et al. Avicenna J Med. .

Abstract

Background SCUBE 1-has been used as a biomarker for the diagnoses of myocardial infarction, stroke, mesenteric ischemia, and gastric cancer in some recent studies. In this study, we investigated the relationship between serum SCUBE-1 levels and return of spontaneous circulation (ROSC) in patients who received cardiopulmonary resuscitation (CPR). Methods Patients over 18 years of age who were not pregnant and received CPR were divided into two groups: those who achieved ROSC and those who died. There were 25 patients in each group. SCUBE-1 and other routine biochemical parameters were studied in blood samples taken at the time of admission. Results There was no significant difference between the age and gender distribution of the patients between the two groups. The SCUBE-1 value of the ROSC group was significantly higher than that of the non-survivor group ( p ˂ 0.05). At a cut-off value of 9 ng/mL, SCUBE-1 had a sensitivity of 100%, a positive predictive value of 65.8%, specificity of 48%, and a negative predictive value of 100% in predicting ROSC. Conclusions The SCUBE-1 values were found to be significantly higher in the ROSC group compared with the non-survivor group.

Keywords: SCUBE−1 protein; cardiopulmonary resuscitation; peptides.

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Conflict of interest statement

Conflict of Interest None declared.

Figures

Fig. 1
Fig. 1
Flowchart of the study.
Fig. 2
Fig. 2
Receiver operating characteristic curves of SCUBE-1 for the prediction of the return of spontaneous circulation
See this image and copyright information in PMC

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