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. 2022 Aug 25:13:980627.
doi: 10.3389/fgene.2022.980627. eCollection 2022.

Incidence of Down Syndrome by maternal age in Chinese population

Yi Song  1 , Song Jieping  1 , Zhou Tianshu  2 , Zhang Zhijun  3 , Zhang Jingxuan  4 , Wang Bo  1
Affiliations

Incidence of Down Syndrome by maternal age in Chinese population

Yi Song et al. Front Genet. .

Abstract

Objective: This study aims to estimate the maternal age-related risk of Down syndrome in an Asian population. Methods: We performed a retrospective data analysis including a total of 206,295 pregnant women who presented for second-trimester maternal serum screening for Down syndrome at Hubei Maternal and Child Health Hospital for the years 2008-2017. Cases were assigned to three groups: ≤26 years of age, 27-33 years of age, and ≥34 years of age. The incidence of Down Syndrome was calculated for each age group. The differences between groups were tested using the chi-square (χ2) test. Results: The incidence of Down syndrome in women ≤26 years of age, 27-33 years of age, and ≥34 years of age was 0.67‰, 0.29‰, and 2.07‰ respectively. Statistically significant difference was found between the three age groups (χ2 = 79.748, p < 0.05). Conclusion: Down syndrome rate was significantly higher in women ≥34 years of age. Younger women (≤26 years of age) had a significantly higher risk for Down's syndrome, compared to women aged 27-33.

Keywords: Asian population; Hubei China; advanced maternal age (AMA); down syndrome; maternal serum screening.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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