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. 2022 Aug 25:13:980627.
doi: 10.3389/fgene.2022.980627. eCollection 2022.

Incidence of Down Syndrome by maternal age in Chinese population

Yi Song  1 , Song Jieping  1 , Zhou Tianshu  2 , Zhang Zhijun  3 , Zhang Jingxuan  4 , Wang Bo  1
Affiliations

Incidence of Down Syndrome by maternal age in Chinese population

Yi Song et al. Front Genet. .

Abstract

Objective: This study aims to estimate the maternal age-related risk of Down syndrome in an Asian population. Methods: We performed a retrospective data analysis including a total of 206,295 pregnant women who presented for second-trimester maternal serum screening for Down syndrome at Hubei Maternal and Child Health Hospital for the years 2008-2017. Cases were assigned to three groups: ≤26 years of age, 27-33 years of age, and ≥34 years of age. The incidence of Down Syndrome was calculated for each age group. The differences between groups were tested using the chi-square (χ2) test. Results: The incidence of Down syndrome in women ≤26 years of age, 27-33 years of age, and ≥34 years of age was 0.67‰, 0.29‰, and 2.07‰ respectively. Statistically significant difference was found between the three age groups (χ2 = 79.748, p < 0.05). Conclusion: Down syndrome rate was significantly higher in women ≥34 years of age. Younger women (≤26 years of age) had a significantly higher risk for Down's syndrome, compared to women aged 27-33.

Keywords: Asian population; Hubei China; advanced maternal age (AMA); down syndrome; maternal serum screening.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Adams M. M., Erickson J. D., Layde P. M., Oakley G. P. (1981). Down's syndrome. recent trends in the United States. JAMA 246 (7), 758–760. 10.1001/jama.246.7.758 - DOI - PubMed
    1. Antonarakis S. E., Skotko B. G., Rafii M. S., Strydom A., Pape S. E., Bianchi D. W., et al. (2020). Down syndrome. Nat. Rev. Dis. Prim. 6 (1), 9. 10.1038/s41572-019-0143-7 - DOI - PMC - PubMed
    1. Bhaumik P., Ghosh P., Ghosh S., Feingold E., Ozbek U., Sarkar B., et al. (2017). Combined association of Presenilin-1 and Apolipoprotein E polymorphisms with maternal meiosis II error in Down syndrome births. Genet. Mol. Biol. 40 (3), 577–585. 10.1590/1678-4685-GMB-2016-0138 - DOI - PMC - PubMed
    1. Bornstein E., Lenchner E., Donnenfeld A., Barnhard Y., Seubert D., Divon M. Y. (2009). Advanced maternal age as a sole indication for genetic amniocentesis; risk-benefit analysis based on a large database reflecting the current common practice. J. Perinat. Med. 37 (2), 99–102. 10.1515/JPM.2009.032 - DOI - PubMed
    1. Chen Y., Qian X., Zhang J., Li J., Chu A., Schweitzer S. O. (2008). Preliminary study into the economic burden of down syndrome in China. Birth Defects Res. A Clin. Mol. Teratol. 82 (1), 25–33. 10.1002/bdra.20409 - DOI - PubMed

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