Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Aug 27;25(9):105015.
doi: 10.1016/j.isci.2022.105015. eCollection 2022 Sep 16.

Interdisciplinary approaches to metastasis

Stephen W Smye  1 , Robert A Gatenby  2
Affiliations

Interdisciplinary approaches to metastasis

Stephen W Smye et al. iScience. .

Abstract

Interdisciplinary research is making a significant contribution to understanding metastasis - one of the grand challenges in cancer research. Examples drawn from apparently unconnected areas of physics, and described at a recent workshop on metastasis, illustrate the value of interdiscplinary thinking.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

None
Image credit—Source: Jill Gallaher, Moffitt Cancer Center, reproduced from Mathematical Oncology https://mathematical-oncology.org/
None
Tentacle growth at a topological defect in a model active nematic (Figure 2C reprinted with kind permission from Metselaar et al. (2019)) Copyright (2019) by the American Physical Society. https://doi.org/10.1103/PhysRevLett.123.208001. Caption supplied by J. M. Yeomans.
See this image and copyright information in PMC

References

    1. Brown R.R., Deletic A., Wong T.H.F. Interdisciplinarity: how to catalyse collaboration. Nature. 2015;525:315–317. - PubMed
    1. Cunningham J., Frank T., Peeters R., Viossat Y., Brown J., Gatenby R. Kateřina Staňková Optimal control to reach eco-evolutionary stability in metastatic castrate-resistant prostate cancer. PLOS One. 2020;8 doi: 10.1371/journal.pone.0243386. - DOI - PMC - PubMed
    1. Fares J., Fares M.Y., Khachfe H.H., Salhab H.A., Fares Y. Molecular principles of metastasis: a hallmark of cancer revisited. Signal Transduct. Targeted Ther. 2020;5:28. doi: 10.1038/s41392-020-0134-x. - DOI - PMC - PubMed
    1. Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell. 2011;144:646–674. - PubMed
    1. Iram S., Dolson E., Chiel J., Julia P., Krishnan N., Güngör Ö., Kuznets-Speck B., Deffner S., Ilker E., Scott J.G. Michael Hinczewski Controlling the speed and trajectory of evolution with counterdiabatic driving. Nat. Phys. 2021;17:135–142. doi: 10.1038/s41567-020-0989-3. - DOI