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Case Reports
. 2022 Sep 5;10(9):e6282.
doi: 10.1002/ccr3.6282. eCollection 2022 Sep.

Cutaneous involvement in relapsed multiple myeloma

Valéry Salle  1 , Christophe Attencourt  2 , Marion Chevalier  1 , Lucile Semeria  3 , Xavier Boulu  1 , Jean-Denis Karam  1 , Amar Smail  1 , Jean Schmidt  1 , Pierre Duhaut  1 , Amandine Dernoncourt  1
Affiliations
Case Reports

Cutaneous involvement in relapsed multiple myeloma

Valéry Salle et al. Clin Case Rep. .

Abstract

Cutaneous involvement in multiple myeloma with extramedullary disease is rare. We report the case of a refractory multiple myeloma patient who developed a cutaneous lesion. Histopathology revealed dermal immature plasma cell infiltrate with a lack of CD138 expression. This cutaneous location was associated with an aggressive clinical course and short survival.

Keywords: cutaneous involvement; extramedullary disease; immature plasma cells; multiple myeloma.

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Conflict of interest statement

There are no conflicts of interest to declare from any author with regard to this publication.

Figures

FIGURE 1
FIGURE 1
Numerous violaceous nodules with infiltrated plaque
FIGURE 2
FIGURE 2
Morphological and immunohistochemical characteristics of the biopsed skin lesion. (A) Focal and perivascular dermal immature plasma cells infiltrate (HPS, 200×). (B) Plasma cells show positivity for MUM1 (IHC, 200×).
FIGURE 3
FIGURE 3
Bone marrow biopsy before skin involvement. (A) Abundant plasma cells infiltration (HE, 200×). (B) Tumor cells show positivity for CD138 (IHC, 200×). (C) The plasma cells predominantly express the lambda light chain (IHC, 200×).
See this image and copyright information in PMC

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