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Case Reports
. 2022 Aug;11(8):2931-2935.
doi: 10.21037/tcr-22-141.

Durable response to crizotinib in an advanced lung adenocarcinoma patient harboring rare CD47-MET fusion: a case report

Junfang Liu  1 , Lijun Shen  1 , Yunyao Qian  1 , Yunpeng Liu  1 , Minhong Su  1 , Li Yi  2
Affiliations
Case Reports

Durable response to crizotinib in an advanced lung adenocarcinoma patient harboring rare CD47-MET fusion: a case report

Junfang Liu et al. Transl Cancer Res. 2022 Aug.

Abstract

Background: MET fusion is a rare type of structure rearrangement, reported only in 0.26% of non-small cell lung cancer (NSCLC). Some uncommon genomic variants, including MET fusions, have been detected with advanced detection technology. Therapeutic option for MET-rearranged NSCLC remains largely uncovered.

Case description: Herein, we described a 72-year-old male patient with a 10-year history of smoking who presented to our hospital with coughing, blood-tinged sputum, chest distress, and anhelation. He was diagnosed with stage IV lung adenocarcinoma harboring a CD47 (EX7)-MET (EX15) fusion, detected by next-generation sequencing (NGS). After one month of crizotinib treatment, the patient showed partial re-expansion of the collapsed right lower lobe, shrinkages of lymph node lesions, and reduced right pleural effusion. The patient achieved partial response (PR) to first-line treatment of crizotinib with a progression-free survival (PFS) of 8 months. Cabozantinib was subsequently administrated, and a short-term PR of fewer than three months was observed. The patient retained CD47-MET fusion and acquired MET D1228E at cabozantinib progression.

Conclusions: This case provided the first clinical evidence for the efficacy of crizotinib in CD47-MET rearranged NSCLC and suggested MET D1228E as a resistance mechanism. NGS is a powerful tool for identifying rare MET gene variants in patients with NSCLC, which should be encouraged in clinical practice.

Keywords: CD47-MET fusion; MET D1228E; Non-small cell lung cancer (NSCLC); cabozantinib; case report.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tcr.amegroups.com/article/view/10.21037/tcr-22-141/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Tumor response to crizotinib treatment. (A) Baseline before treatment; (B) 1 month after crizotinib; (C) 5 months after crizotinib.
Figure 2
Figure 2
Illustration of CD47-MET fusion. The CD47-MET rearrangement had breakpoints in the CD47 intron 7 and MET intron 14, which conferred the fusion of CD47 exon 7 to MET exon 15. PMT, promoter; IVS, intervening sequence.
See this image and copyright information in PMC

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