Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Feb;36(2):e4830.
doi: 10.1002/nbm.4830. Epub 2022 Sep 22.

A robust adiabatic constant amplitude spin-lock preparation module for myocardial T1ρ quantification at 3 T

Yuxin Yang  1   2 , Che Wang  1   2 , Yuanyuan Liu  1 , Zhongmin Chen  2 , Xin Liu  1 , Hairong Zheng  1 , Dong Liang  1 , Yanjie Zhu  1
Affiliations

A robust adiabatic constant amplitude spin-lock preparation module for myocardial T1ρ quantification at 3 T

Yuxin Yang et al. NMR Biomed. 2023 Feb.

Abstract

T1ρ quantification has the potential to assess myocardial fibrosis without contrast agent. However, its preparation spin-lock pulse is sensitive to B1 and B0 inhomogeneities, resulting in severe banding artifacts in the heart region, especially at high magnetic field such as 3 T. We aimed to design a robust spin-lock (SL) preparation module that can be used in myocardial T1ρ quantification at 3 T. We used the tan/tanh pulse to tip up and tip down the magnetization in the spin-lock preparation module (tan/tanh-SL). Bloch simulation was used to optimize pulse shape parameters of the tan/tanh with a pulse duration (Tp ) of 8, 4, and 2 ms, respectively. The designed tan/tanh-SL modules were implemented on a 3-T MR scanner. They were evaluated in phantom studies under three different cases of B0 and B1 inhomogeneities, and tested in cardiac T1ρ quantification of healthy volunteers. The performance of the tan/tanh-SL was compared with the composite SL preparation pulses and the commonly used hyperbolic secant pulse for spin-lock (HS-SL). Feasible pulse shape parameters were obtained using Bloch simulation. Compared with HS-SL, the quantification error of tan/tanh-SL was reduced by 27.7% for Tp = 8 ms (mean ∆Q = 126.15 vs. 174.42) and 75.6% for Tp = 4 ms (mean ∆Q = 136.65 vs. 559.53). In the phantom study, tan/tanh-SL was less sensitive to B1 and B0 inhomogeneity compared with composite SL pulses and HS-SL. In cardiac T1ρ quantification, the T1ρ maps using tan/tanh-SL showed fewer banding artifacts than using composite SL pulses and HS-SL. The proposed tan/tanh-SL preparation module greatly improves the robustness to B0 and B1 field inhomogeneities and can be used in cardiac T1ρ quantification at 3 T.

Keywords: adiabatic constant amplitude spin-lock preparation; myocardial T1ρ mapping.

PubMed Disclaimer

References

REFERENCES

    1. Kuruvilla S, Adenaw N, Katwal AB, Lipinski MJ, Kramer CM, Salerno M. Late gadolinium enhancement on cardiac magnetic resonance predicts adverse cardiovascular outcomes in nonischemic cardiomyopathy: a systematic review and meta-analysis. Circ Cardiovasc Imaging. 2014;7(2):250-258. doi:10.1161/CIRCIMAGING.113.001144
    1. Kwong RY, Chan AK, Brown KA, et al. Impact of unrecognized myocardial scar detected by cardiac magnetic resonance imaging on event-free survival in patients presenting with signs or symptoms of coronary artery disease. Circulation. 2006;113(23):2733-2743. doi:10.1161/CIRCULATIONAHA.105.570648
    1. Weinreb JC, Rodby RA, Yee J, et al. Use of intravenous gadolinium-based contrast media in patients with kidney disease: consensus statements from the American College of Radiology and the National Kidney Foundation. Kidney Med. 2021;3(1):142-150. doi:10.1016/j.xkme.2020.10.001
    1. Kanda T, Ishii K, Kawaguchi H, Kitajima K, Takenaka D. High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: relationship with increasing cumulative dose of a gadolinium-based contrast material. Radiology. 2014;270(3):834-841. doi:10.1148/radiol.13131669
    1. Kamesh Iyer S, Moon B, Hwuang E, et al. Accelerated free-breathing 3D T1ρ cardiovascular magnetic resonance using multicoil compressed sensing. J Cardiovasc Magn Reson. 2019;21(1):1-11. doi:10.1186/s12968-018-0507-2

Publication types

LinkOut - more resources