Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Sep 1;11(5):441-452.
doi: 10.1097/APO.0000000000000557.

Corneal Crosslinking: Present and Future

Lize Angelo  1 , Akilesh Gokul Boptom, Charles McGhee, Mohammed Ziaei
Affiliations
Free article
Review

Corneal Crosslinking: Present and Future

Lize Angelo et al. Asia Pac J Ophthalmol (Phila). .
Free article

Abstract

Keratoconus is a progressive corneal thinning disorder that can lead to vision loss. In the last 2 decades, corneal crosslinking (CXL) has emerged as an effective method to halt the progression of keratoconus and reduce the number of patients requiring keratoplasty. The procedure has been adopted globally and has evolved to become a part of combination treatments to regularize the cornea and improve visual outcomes. CXL has even been extrapolated in managing other ocular pathologies such as progressive myopia, infectious keratitis, and bullous keratopathy. This review aims to summarize the current role of CXL in keratoconus and its alternative uses, and provide insights into future developments in this fast-developing field.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to disclose.

References

    1. Ziaei M, Barsam A, Shamie N, et al. Reshaping procedures for the surgical management of corneal ectasia. J Cataract Refract Surg. 2015;41:842–872.
    1. Goh YW, Gokul A, Yadegarfar ME, et al. Prospective clinical study of keratoconus progression in patients awaiting corneal cross-linking. Cornea. 2020;39:1256–1260.
    1. Crawford AZ, Zhang J, Gokul A, et al. The enigma of environmental factors in keratoconus. Asia Pac J Ophthalmol (Phila). 2020;9:549–556.
    1. Althomali TA, Al-Qurashi IM, Al-Thagafi SM, et al. Prevalence of keratoconus among patients seeking laser vision correction in Taif area of Saudi Arabia. Saudi J Ophthalmol. 2018;32:114–118.
    1. McGhee CNJ, Kim BZ, Wilson PJ. Contemporary treatment paradigms in keratoconus. Cornea. 2015;34:16–23.

LinkOut - more resources