Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Aug;173(4):553-559.
doi: 10.1007/s10517-022-05588-y. Epub 2022 Sep 12.

Differential Markers of Subpopulations of Epithelial Cells of the Larynx in Squamous Cell Carcinoma

I V Arutyunyan  1   2 , A G Soboleva  3 , K B Gordon  4   5 , D S Kudashkina  6 , D A Miroshnichenko  6 , A P Polyakov  6 , I V Rebrikova  6 , A V Makarov  4   3 , A V Lokhonina  4   3 , T Kh Fatkhudinov  4   3
Affiliations

Differential Markers of Subpopulations of Epithelial Cells of the Larynx in Squamous Cell Carcinoma

I V Arutyunyan et al. Bull Exp Biol Med. 2022 Aug.

Abstract

In squamous cell carcinoma of the larynx, the population of epithelial cells in the tumor tissue is initially heterogeneous and, in addition to tumor cells invading the organ mucosa, includes normal epithelial cells of protein-mucous glands and cells of the stratified epithelium covering the mucous membrane. A search for differential markers to separate these subpopulations was carried out. The surface marker CD44 and cytokeratins 5 and 17 that are often used to verify carcinoma cells, are common markers for all epithelial cells of the larynx. In highly differentiated carcinoma, subpopulations of normal and tumor epithelial cells can be separated by the level of expression of cytokeratins 10 and 18 and nuclear markers Ki-67 and p63. However, in moderately differentiated carcinoma, tumor cells and normal cells of the basal layer of the stratified epithelium covering the mucous membrane of the larynx have similar phenotypes, which should be taken into account when conducting experimental studies.

Keywords: differential markers; epithelial cells; larynx; squamous cell carcinoma.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Ali AA, Al-Jandan BA, Suresh CS. The importance of ctokeratins in the early detection of oral squamous cell carcinoma. J. Oral Maxillofac. Pathol. 2018;22(3):441. https://doi.org/10.4103/jomfp.JOMFP_238_17 - DOI - PubMed - PMC
    1. Borba M, Cernea C, Dias F, Faria P, Bacchi C, Brandão L, Costa A. Expression profile of p63 in 127 patients with laryngeal squamous cell carcinoma. ORL J. Otorhinolaryngol. Relat. Spec. 2010;72(6):319-324. https://doi.org/10.1159/000319904 - DOI - PubMed
    1. Canning M, Guo G, Yu M, Myint C, Groves MW, Byrd JK, Cui Y. Heterogeneity of the head and neck squamous cell carcinoma immune landscape and its impact on immunotherapy. Front. Cell Dev. Biol. 2019;7:52. https://doi.org/10.3389/fcell.2019.00052 - DOI - PubMed - PMC
    1. Caruntu A, Moraru L, Lupu M, Ciubotaru DA, Dumitrescu M, Eftimie L, Hertzog R, Zurac S, Caruntu C, Voinea OC. Assessment of histological features in squamous cell carcinoma involving head and neck skin and mucosa. J. Clin. Med. 2021;10(11):2343. https://doi.org/10.3390/jcm10112343 - DOI - PubMed - PMC
    1. Chatzkel J, Lewis JS Jr, Ley JC, Wildes TM, Thorstad W, Gay H, Daly M, Jackson R, Rich J, Paniello R, Nussenbaum B, Liu J, Siegel BA, Dehdashti F, Adkins D. Correlation of Ki-67 proliferative antigen expression and tumor response to induction chemotherapy containing cell cycle-specific agents in head and neck squamous cell carcinoma. Head Neck Pathol. 2017;11(3):338-345. https://doi.org/10.1007/s12105-016-0775-9 - DOI - PubMed

LinkOut - more resources