Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Sep 12;17(9):e0274256.
doi: 10.1371/journal.pone.0274256. eCollection 2022.

Defining explicit definitions of potentially inappropriate prescriptions for antidiabetic drugs in patients with type 2 diabetes: A systematic review

Erwin Gerard  1   2 , Paul Quindroit  1 , Madleen Lemaitre  3   4 , Laurine Robert  1   2 , Sophie Gautier  5 , Bertrand Decaudin  2   6 , Anne Vambergue  3   7 , Jean-Baptiste Beuscart  1
Affiliations

Defining explicit definitions of potentially inappropriate prescriptions for antidiabetic drugs in patients with type 2 diabetes: A systematic review

Erwin Gerard et al. PLoS One. .

Abstract

Introduction: Potentially inappropriate prescriptions (PIPs) of antidiabetic drugs (ADs) (PIPADs) to patients with type 2 diabetes mellitus (T2DM) have been reported in some studies. The detection of PIPs in electronic databases requires the development of explicit definitions. This approach is widely used in geriatrics but has not been extended to PIPADs in diabetes mellitus. The objective of the present literature review was to identify all explicit definitions of PIPADs in patients with T2DM.

Materials and methods: We performed a systematic review of the literature listed on Medline (via PubMed), Scopus, Web of Science, and, Embase between 2010 and 2021. The query included a combination of three concepts ("T2DM" AND "PIPs" AND "ADs") and featured a total of 86 keywords. Two independent reviewers selected publications, extracted explicit definitions of PIPADs, and then classified the definitions by therapeutic class and organ class.

Results: Of the 4,093 screened publications, 39 were included. In all, 171 mentions of PIPADs (corresponding to 56 unique explicit definitions) were identified. More than 50% of the definitions were related to either metformin (34%) or sulfonylureas (29%). More than 75% of the definitions were related to either abnormal renal function (56%) or age (22%). In addition, 20% (n = 35) mentions stated that biguanides were inappropriate in patients with renal dysfunction and 17.5% (n = 30) stated that sulfonylureas were inappropriate above a certain age. The definitions of PIPADs were heterogeneous and had various degrees of precision.

Conclusion: Our results showed that researchers focused primarily on the at-risk situations related to biguanide prescriptions in patients with renal dysfunction and the prescription of sulfonylureas to older people. Our systematic review of the literature revealed a lack of consensus on explicit definitions of PIPADs, which were heterogeneous and limited (in most cases) to a small number of drugs and clinical situations.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. PRISMA flow diagram, describing the selection and screening process.
See this image and copyright information in PMC

References

    1. Santé Publique France (2018) Le poids du diabète en France en 2016. Synthèse épidémiologique. Saint-Maurice, France.
    1. Spector WD, Limcangco R, Furukawa MF, Encinosa WE (2017) The Marginal Costs of Adverse Drug Events Associated With Exposures to Anticoagulants and Hypoglycemic Agents During Hospitalization. Medical Care 55(9):856–863. doi: 10.1097/MLR.0000000000000780 - DOI - PubMed
    1. Jönsson B (2002) Revealing the cost of Type II diabetes in Europe. Diabetologia 45(Suppl 1):S5–S12. doi: 10.1007/s00125-002-0858-x - DOI - PubMed
    1. Spinewine A, Schmader KE, Barber N, et al. (2007) Appropriate prescribing in elderly people: how well can it be measured and optimised? Lancet 370(9582):173–184. doi: 10.1016/S0140-6736(07)61091-5 - DOI - PubMed
    1. Brook RH, Davies-Avery A, Greenfield S, et al. (1977) Assessing the Quality of Medical Care Using Outcome Measures: An Overview of the Method. Medical Care 15(9):i-vii+ix-x+1–165. - PubMed

Publication types