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. 2022 Nov:160:105418.
doi: 10.1016/j.neuint.2022.105418. Epub 2022 Sep 9.

Intact amphetamine-induced behavioral sensitization in mice with increased or decreased neuronal glutamate transporter SLC1A1/EAAT3

Muhammad O Chohan  1 , Hannah Yueh  1 , Halli Fein  2 , Jared M Kopelman  3 , Susanne E Ahmari  4 , Jeremy Veenstra-VanderWeele  5
Affiliations

Intact amphetamine-induced behavioral sensitization in mice with increased or decreased neuronal glutamate transporter SLC1A1/EAAT3

Muhammad O Chohan et al. Neurochem Int. 2022 Nov.

Abstract

Repeated amphetamine treatment results in locomotor sensitization, a phenomenon that may relate to the development of psychosis and addiction. Evidence suggests that interactions between dopaminergic and glutamatergic systems are involved in amphetamine sensitization. We previously demonstrated that the neuronal excitatory amino acid transporter (Slc1a1/EAAT3) produces bidirectional, expression-dependent effects on the response to acute amphetamine. Here, using mice with decreased or increased expression of EAAT3, we found that chronic alterations in EAAT3 expression do not significantly impact amphetamine-induced locomotor sensitization. Compensation by other glutamate transporters cannot be ruled out in this important neuroadaptive phenomenon.

Keywords: Amphetamine; Basal ganglia; Dopamine; EAAT3; Glutamate transporters; Sensitization.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Jeremy Veenstra-VanderWeele reports financial support was provided by National Institutes of Health. Jeremy Veenstra-VanderWeele reports financial support was provided by Simons Foundation. Jeremy Veenstra-VanderWeele reports financial support was provided by Roche. Jeremy Veenstra-VanderWeele reports financial support was provided by Novartis. Jeremy Veenstra-VanderWeele reports financial support was provided by Seaside Therapeutics. Jeremy Veenstra-VanderWeele reports financial support was provided by Janssen Pharmaceuticals Inc. Jeremy Veenstra-VanderWeele reports financial support was provided by Yamo. Jeremy Veenstra-VanderWeele reports financial support was provided by MapLight. Jeremy Veenstra-VanderWeele reports financial support was provided by Acadia Pharmaceuticals Inc. Susanne E. Ahmari reports financial support was provided by National Institutes of Health. Susanne E. Ahmari reports financial support was provided by International OCD Foundation. Susanne E. Ahmari reports financial support was provided by One Mind Foundation. Susanne E. Ahmari reports financial support was provided by Brain Research Foundation. Susanne E. Ahmari reports financial support was provided by Klingenstein-Simons Foundation. Susanne E. Ahmari reports financial support was provided by McKnight Foundation. Susanne E. Ahmari reports financial support was provided by Foundation for OCD Research. Jeremy Veenstra-VanderWeele reports a relationship with Roche that includes: consulting or advisory. Jeremy Veenstra-VanderWeele reports a relationship with Autism Speaks that includes: board membership. Jeremy Veenstra-VanderWeele reports a relationship with Brain and Behavior Research Foundation that includes: board membership. Jeremy Veenstra-VanderWeele reports a relationship with Autism Biomarkers Consortium for Clinical Trials that includes: board membership. Jeremy Veenstra-VanderWeele reports a relationship with Autism Research that includes: board membership. Jeremy Veenstra-VanderWeele reports a relationship with JAMA Psychiatry that includes: board membership. Jeremy Veenstra-VanderWeele reports a relationship with Journal of the American Academy of Child and Adolescent Psychiatry that includes: board membership. Jeremy Veenstra-VanderWeele reports a relationship with Autism that includes: board membership. Jeremy Veenstra-VanderWeele reports a relationship with Journal of Neurodevelopmental Disorders that includes: board membership. Jeremy Veenstra-VanderWeele reports a relationship with Wiley that includes: consulting or advisory. Jeremy Veenstra-VanderWeele reports a relationship with Spinger Nature that includes: consulting or advisory. Susanne E. Ahmari reports a relationship with International OCD Foundation that includes: board membership. Susanne E. Ahmari reports a relationship with Orchard that includes: board membership. Susanne E. Ahmari reports a relationship with Brain and Behavior Research Foundation that includes: board membership. Susanne E. Ahmari reports a relationship with Neuropsychopharmacology that includes: board membership. Susanne E. Ahmari reports a relationship with Springer Nature that includes: consulting or advisory.

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