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Review
. 2022 Sep;56(1):151-168.
doi: 10.1016/j.yasu.2022.02.006.

What Surgeons Need to Know About Gene Therapy for Cancer

Shanmugappiriya Sivarajah  1 , Kevin Emerick  1 , Howard L Kaufman  2
Affiliations
Review

What Surgeons Need to Know About Gene Therapy for Cancer

Shanmugappiriya Sivarajah et al. Adv Surg. 2022 Sep.

Abstract

The broad field of gene therapy offers numerous innovative approaches for cancer treatment. An understanding of the different modalities including gene replacement therapy, cancer vaccines, oncolytic viruses, cellular therapy, and gene editing is essential for managing patients with neoplastic disease. As in other areas of oncology, the surgeon plays a pivotal role in the diagnosis and treatment of the disease. This review focuses on what the clinical surgeon needs to know to optimize the benefit of gene therapy for patients with cancer.

Keywords: Cancer; Cell therapy; Gene editing; Gene therapy; Immunotherapy; Oncolytic viruses.

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