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. 2022 Sep 12;8(1):116.
doi: 10.1038/s41531-022-00382-z.

Basal ganglia engagement during REM sleep movements in Parkinson's disease

Ajay K Verma #  1 , Sergio Francisco Acosta Lenis #  1 , Joshua E Aman  1 , David Escobar Sanabria  1 , Jing Wang  1 , Amy Pearson  1 , Meghan Hill  1 , Remi Patriat  2 , Lauren E Schrock  1 , Scott E Cooper  1 , Michael C Park  1   3 , Noam Harel  2   3 , Michael J Howell  1 , Colum D MacKinnon  1 , Jerrold L Vitek  1 , Luke A Johnson  4
Affiliations

Basal ganglia engagement during REM sleep movements in Parkinson's disease

Ajay K Verma et al. NPJ Parkinsons Dis. .

Abstract

To elucidate the role of the basal ganglia during REM sleep movements in Parkinson's disease (PD) we recorded pallidal neural activity from four PD patients. Unlike desynchronization commonly observed during wakeful movements, beta oscillations (13-35 Hz) synchronized during REM sleep movements; furthermore, high-frequency oscillations (150-350 Hz) synchronized during movement irrespective of sleep-wake states. Our results demonstrate differential engagement of the basal ganglia during REM sleep and awake movements.

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Conflict of interest statement

J.E.A., N.H., R.P., M.C.P., and J.L.V. declares no competing non-financial interest but the following competing financial interests. J.E.A. – Consultant for Surgical Information Sciences Inc. N.H. - Consultant and a shareholder for Surgical Information Sciences Inc. R.P. - Consultant for Surgical Information Sciences Inc. M.C.P. - Listed faculty for University of Minnesota Educational Partnership with Medtronic, Inc., Minneapolis, MN, Consultant for: Zimmer Biomet, Synerfues, Inc, NeuroOne, Boston Scientific. Grant/Research support from: Medtronic, Inc., Boston Scientific, Abbott, SynerFuse, Inc., and Fasikl, Inc. J.L.V. - Dr. Vitek serves as a consultant for Medtronic, Boston Scientific and Abbott. He also serves on the Executive Advisory Board for Abbott and is a member of the scientific advisory board for Surgical Information Sciences. He has research support through the National Institutes of Health. All other authors have no competing interest to disclose.

Figures

Fig. 1
Fig. 1. Movement-related beta and high-frequency oscillations recorded from DBS leads in the GPi of PD patients in awake and REM sleep states.
a Trial-averaged spectrograms aligned to movement onset showing beta (13–35 Hz) desynchronization in the GPi during wakeful volitional movement (reaching task, see Methods). b Spectrograms showing beta synchronization in the GPi during REM sleep movements. c Distributions of beta band power modulation (relative to pre movement baseline) during wake movements (blue) and REM sleep movements (red). All data distributions were significantly different from zero (Wilcoxon signed rank (WSR) test, p < 0.05). d, e Trial-averaged spectrograms aligned to movement onset show synchronization of high-frequency oscillations (HFO, 150–350 Hz) in the GPi during wakeful and REM sleep movements, respectively. f Distributions of HFO band power modulation (relative to pre movement baseline) during wake movements (blue) and REM sleep movements (red). All data distributions were significantly different from zero (WSR test, p < 0.05). Boxplot elements: center line, median; box limits, upper and lower quartiles; whiskers, 1.5 × interquartile range; +sign, outliers.
See this image and copyright information in PMC

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