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. 2023 Mar;37(4):787-789.
doi: 10.1038/s41433-022-02236-7. Epub 2022 Sep 12.

Intraocular inflammasome signalling in failed corneal transplants

Andres Serrano  1   2 , Angela Gomez-Bedoya  1   2 , Arianna A Tovar  1   2 , Marcela Huertas-Bello  1   2 , Guillermo Amescua  1 , Ellen H Koo  1 , Florence Cabot  1 , Roey Hadad  3 , Sander R Dubovy  1 , Juan Pablo de Rivero Vaccari  3 , Alfonso L Sabater  4   5
Affiliations

Intraocular inflammasome signalling in failed corneal transplants

Andres Serrano et al. Eye (Lond). 2023 Mar.
No abstract available

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Conflict of interest statement

JPdRV is a co-founder and managing member of InflamaCORE, LLC and has licensed patents on inflammasome proteins as biomarkers of injury and disease and targeting inflammasome proteins for therapeutic purposes. JPdRV is a Scientific Advisory Board Member of ZyVersa Therapeutics.

Figures

Fig. 1
Fig. 1. Inflammasome protein expression in the aqueous humour of patients with corneal graft failure.
Expression of ASC (A), IL-18 (B), and IL-1β (C) in the AqH of patients with CGF. N. 12 = Healthy eyes; N. 7 = CGF. Data presented as mean ± SEM. *p = 0.0072, **p < 0.0001, ****p = 0.0361. The lower limit of quantitation of ASC, IL-18, and IL-1β was assumed in samples with undetected levels of these proteins (13.00, 0.39, and 0.20 pg/ml, respectively).
Fig. 2
Fig. 2. Expression of GSDM-D in the graft of patients with corneal graft failure.
GSDM-D expression (arrow heads) in failed grafts from three different patients compared to healthy donor corneas (controls). A higher expression of GSDM-D was observed in the failed grafts from patients with corneal graft failure. Stromal lamellar thickness was greater in these patients, consistent with the decreased transparency in failed graft corneas. Green: GSDM-D; Blue: nuclear staining (DAPI); Magnification: ×40.
See this image and copyright information in PMC

References

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